I have had PMR and GCA for 8 years and am now down to 7 mg of Prednisone , trying to reduce but without success. However in March 2017 I was diagnosed with Polycythemia and was put on 75 mg of Aspirin and 500 mg of Hydroxycarbamide. , I have just read on this forum that Aspirin and Prednisone should not be given together because of drug interaction. I also take Ranitidine, Curcumin, Serrapeptase and Thymo-Lyph. The last item I have been given by a Health Practitioner for my compromised immune system. However I am very concerned about the interaction of Aspirin and Pred. I queried this with my Haematologist when first diagnosed with Polycythemia but she said it was ok. However since I have started taking the two drugs together I have had various unidentified symptoms, eg extreme fatigue, feeling sick, especially in the mornings and intermittent headaches, none of these were present until recently. I have asked the pharmacist who was very non-commital and said I should query it with my consultant. I am obviously very concerned about this interaction. Some reassurance from this site would be great. Happy New Year everyone.