AMA negative but ANA positive

[Liz_K]

Hi there, I was diagnosed with PBC just over two years ago, which was such a shock to me me as I had no idea about this condition (only visited doctor for a routine check-up 😧!!) Have been on Urso ( 2 years) but my ALP and GGT are still high!! Had biopsy and fibroscan 10.1 Specialist says I am stage 3. Now as well as Urso I have started on 5mg Obeticholic acid (Ocaliva) daily. Hopefully this will improve my LFT's. I would love to hear from others diagnosed as ANA positive. I am so pleased I found this site and good to know that I'm not alone with this rare and frustrating condition (thankfully asymptomatic at present).

thanks Liz

[witchiegirl]

Hi Liz I’m AMA negative and ANA positive. I’m being treated for an overlap syndrome where there are features of AIH and PBC. I had a liver biopsy which showed involvement in my liver as well as my bile ducts. This was some years ago and I’m doing well on an immunosuppressant and Urso.