good morning.
in the past days i am reading about the activation of out killer T cells (natural killer T cells -NKT) witch i understand that are responsible for distroing the small ducts.
i also saw that NKT are triggered by diferent bacteria
I understand that this bacteria arrives in our body and i belive that is the triggering thing for Pbc
we also need to know if we can treat it and if we will have it no more , the NKT cells will stop distroing our small ducts in our livers.
I think that we should all make some research obout this bacteria and open a new chapter for this illness.There are many studies on the net about this bacteria and the damages that she is doing.
For Example at Milan in a study: All 79 pacients with Pbc had Novosphingobium aromaticivorans
Another study: When the researchers injected mice with the bacterium, it prompted the production of autoantibodies against the mitochondrial enzyme complex in similar fashion to that observed in patients. This triggered chronic autoimmunity that damaged small bile ducts in the animal's livers. The autoimmune process was mediated by T cells (a white blood cell important to immune response), but early disease onset required the participation of Natural Killer T cells after they selectively recognized glycosphingolipid antigens on the cell wall surface of Novosphingobium aromaticivorans.
Other studies are sayng that also H priory bacteria can trigger pbc or more important can trigger reaction for mithocondrial enzime and i think that as long as the bacteria is in our body the Nkt s are in reaction with our ducts in liver.
My thinking is that Urso/Ocaliva is only flushing the liver and is lowering the effect of our Nkt cells actions but this is not what we really want.
i think that we want to stop Nkt to do what they are doing
So if Nkt is triggered by a bacteria like :
Escherichia coli
Mycoplasma.
Bogdanos et al.
Helicobacter pylori
Novosphingobium aromaticivorans.
that are the major targets of cross-reactivity with human pyruvate dehydrogenase in PBC, strengthening the fact that microbial exposure may be instrumental to the appearance and/or maintenance of AMA responses by a cross-reactive mechanism , than we should test ourself for all this bacterias and cure them.
Last year in march i found that i have Ama positive and also had ast and alt high.
At the same time i found out that i have H pylori bacteria at stomach endoscopy.I had treatment for H pylori and surprise: Ama went from Positive to Negative.
It is clear that Ama witch is in close reaction with NKt are triggered by something witch can be different for all of us but the trigger(a bacteria for example ) keep this reaction and as a result our small liver ducts are destroied.
As i said, i think we all need to know what bacteria from the list we are positive at and cure it.After that i think our Ama must go to Negative.
Urso is only slowing the progression.We need to stop the progression
The liver is the only organ that can regenerate itself.If we could stop the agression of the nkt, i think that is the answer