I've been doing some research and can't seem to find a definitive response. Now, I know that smoking is terrible.. for anyone, especially someone with PBC (I have not been diagnosed, by the way, but it has been confirmed that I have a positive AMA.. Also, my mother & aunt both have PBC so, i'm pretty confident that I have early stage PBC). I have quit smoking since my AMA has come back positive. My question is, does anyone know if a HISTORY of smoking has a huge effect on PBC?? I'm so scared that my history of smoking will cause the the PBC progress faster than usual or something. BTW, as of right now all of my liver function tests are normal and I am asymptomatic. Has anyone on the board with PBC have a history of smoking or know any info regarding this? Thank you so much!