Can somebody orient me. I was diagnosing with pbc three months ago and started on Urso with a great response. Then two weeks ago I visited my hepatoligist and she said I had overlap syndrome which I was proscribed prednisone and azathioprina. So yesterday I took my labs and they came back a little higher than two weeks ago. My question is... Is this normal at first or is the meds affecting more my liver. Should I ask for a liver biopsy to 100 % sure of the diagnosis. I need some advise.