If I get past the screening phase I may be participating in this drug trial. It is aimed at people between 18 and 75 who have a PBC diagnosis with raised levels of ALP that have not come down using Ursofalk (my ALP at last blood test was 730 for example). You need to have been on a stable dose of Ursofalk for the last year and have these raised ALPs. If this sounds like you they are still recruiting at spots around Australia. It is also being conducted in the USA.
If you google clinical trials NGM282 it will come up. I am doing this at POW in Sydney. Will let you no how it goes. As with a lot of drug trials there is a placebo as well so I have a 2 in 3 chance of getting the drug....but you've got to be in it to win it and even if you don't, it's for the good of everyone else.