Just got back from the gastro....he started me on 10mg of methotrexate once a week last month after my blood tests went up dramatically after a month on Ursofalk. Those results are in my other post. Bilirubin is back down to 46 from 76 and the ALP has dropped from 768 to 642. GGT, AST and ALT also down (383, 224 and 432). He has decided to increase the dose from 10 to 15mg per week so will see how this all goes. I am still taking 1250mg of Ursofalk per day as well. Hopefully this combination therapy is working and proves to be a breakthrough. Is anyone else out there trying this combo? Have heard some doctors don't agree with using methotrexate.