switching/alternating Hydroxocobalamin and cyanocobalamin?

[Regenallotment]

excuse my ignorance but I thought I’d check with those that know before I blindly go doing something silly.

I was reading the NHS B12 pages and saw they only offer hydroxcobalamin and they suggest this lasts longer. So I’ve ordered some Pascoe to try.

I have stock of cyanocobalamin and use that twice to 3 times a week. can I just switch?

Can I alternate?

Any tips?

I notice Pascoe is more volume, does that make a difference?

My symptoms are tingling numbness pins and needles in arms, balance, anxiety, concentration, memory, oh and poor digestion/elimination. These dissipate when I inject EOD or E2D.

Thanks🌱

[wedgewood]

It’s fine to alternate between Hydroxocobalamin and Cynocobalamin. It’s Hevert that has more volume ( 1mg x 2ml) ampoule

Pascoe Hydroxocobalamin B12 depot is 1.5mg x 1ml

Pasco makes a 1mg x 1ml Cynocobalamin B12 ampoule .

I’ll send you an information sheet that I’ve compiled .

Best wishes .

[Regenallotment in reply to wedgewood]

Brilliant thanks so much 🙏

[Frank77]

Hello. I have been self-injecting on a daily basis for about 3 years now. Before that I injected every other day for a couple of years. I use both hydroxycobalamin (Pascoe) and cyanocobalamin. I alternate between the two, so one day hydro, the next cyano. Reason for this is that I spend much of my time in Eastern Europe, including Ukraine and Russia, where hydroxycobalamin is not available but cyano is obtainable without prescription, as well as being extraordinarily cheap… So I always order 100 ampules of hydroxycobalamin from Germany when I am home in Ireland and eke it out with cyano. Works well for me - symptoms are pretty much under control. Good luck to you!

[Regenallotment in reply to Frank77]

Thanks so much, this is reassuring. Much appreciated 🌱

[scnuke]

Due to the shortage of hydroxocobalamin in the USA, I started alternating it with Cyano. I inject twice daily and I would use hydro in the AM and cyano in the PM. No real issue that I can tell. I order the 1500 mcg hydro from Pascoe, but my local Walgreens has gotten stock back and I am going to pick up my 6, 30ml vials of hydro today so I will be switching back to all hydro.

[Regenallotment in reply to scnuke]

Thanks,this is helpful . Sorry to hear about your supply issues that sounds rough. Glad you have something sorted. Do you notice any difference between the types cyano x hydroxy? Sounds like you have a preference. Just curious. Had my first hyroxy IM SI this morning and calf muscle knot melted away in minutes …. Not sure if that was a coincidence 🤣

[scnuke]

I saw more improvement with hydroxy compared to when I first started with cyano.