I do believe that 2 days of a 33% lower dose would definitely be noticeable for me, and 2 days is about the amount of time it takes my body to react to missing a dose or having a lower dose. I generally inject 1000 mcg daily but occasionally I miss a day or use a 500 mcg vial (which I bought when 1000 mcg vials weren't available). Neuropathy is far and away my main issue (after 3 years of daily injections) and is the reason I inject daily, and that symptom is, in my experience, very sensitive to decreases in dosage or missed injections. I use cyano for IM injections and hydroxy for SQ injections. I have also used methyl when available. For me it seems like consistency is the key more so than type of B12, but your mileage may vary. Hope you figure it out and get some relief soon. ❤️
Thankyou 😀 I think it may well be the reduced dose that has caused a flare up of symptoms... I injected again with cyanocobalamin today... and the tingling has gotten even worse.. so it's back to hydroxocobalamin tomorrow..hopefully it will settle down
Even with consistent daily injections, my tingling and vibrating worsen with stress, illness, strenuous activity, and lack of sleep, so that is something to keep in mind, as well. 🙂
It's been roughly about the same for the last few months..but has definitely felt worse today... along with my hands were shaking... I will go back to the hydroxocobalamin and see if there is any difference
I was getting them from vitaminb12online.com, but they closed due to COVID. 😔 The list of places that ship to the US has really shrunk in the last 3 years.
I have been on injections for about a year...daily for around 9 months... I was still having neurological symptoms so wanted to try cyanocobalamin to see if any better
Yes... I know that cyanocobalamin is only in the body for around 24 hours compared to around 48 for hydroxocobalamin.. but I didn't expect to notice such a difference I've injected cyanocobalamin again today.. so for 3 days now...
I have tingling and burning that's more noticeable than usual
Slightly off at a tangent, but I have noticed a difference in result with different types of B12 injections. I have a functional b12 deficiency (MMA levels that remain high despite treatment) and also an autoimmune B12 deficiency (GPC ab and gastritis). I am now self-injecting, but last summer I wasn’t, and needed to top up the injections that I was getting from GP (every 3 months). I booked into two different beauty clinics to pay for injections over a few weeks, and I found that following injections at one of the clinics I had more energy but still had the symptoms (tingling legs and episodic weakness in hands), compared to injections from the GP, which improved energy and reduced / got rid of the symptoms. I found out after my second beauty clinic appt that it was methylcobalamin. So I think I respond better to hydroxocobalamin. I have understood from other posts that hydroxocobalamin converts to both methylcobalamin and adenosylcobalamin in the body which are both required for slightly different processes (sorry of o have got this wrong!). From my experience with the methylcobalamin it led me to think that maybe the functional deficiency that I have is perhaps associated with the adenosylcobalamin side of things - which methylcobalamin wouldn’t address…
I have read that many people in holland had to change brands of hydro because of supply problems. Many reported that some of their symptoms returned when the Lu changed brands. I am new to all this and use Pascoe myself. But I thought I would let you know that many people on the Dutch groups reported a slight worsening when they changed brands and most of them settled down…
hi, I was wondering if you could post a link to the Dutch groups where these conversations are happening? Just switched to Pascoe from rotexmedica/panpharma today and panicking as it doesn’t feel like it’s working
My experience is any reduction in B12 has been a definitive negative within 5 days and it takes 3 weeks for me to get back to where I was when I started the decrease.
Any increase is positive in about 10 days. The first few days I am more tired but not more fatigued as I sleep and am less tired. Then for about 6 days I experience more intense peripheral nephropathy including sporadic lightning flashes of pain. Then I know for sure the increase is positive. Currently administering B12 four times a day. .50 mg SC or 2 mg SL.
I have tried both and here is my experience. Both Hydroxocobalamin and Methylcobalamin are habit-forming, in that both require a regular injection and any reduction in the dose/frequency leads to very bad symptoms for me. Also, the serum B12 numbers go way beyond 2000 (upto 6000 or so) and it is not good. On Cyanocobalamin injections, I could get off them after some time. I think the body does not like very frequent injections. Better to be off them and on monthly cyanocobalamin injections and let the body heal. On cyanocobalamin injections, my serum B12 also came down to 1600 which is closer to normal, so I think cyanocobalamin is better (Research shows that very high serum B12 is related to antibodies to transcobalamin, so I guess both Hydroxocobalamin and Methylcobalamin lead to this and hence, not good).
I have needed daily cyano injections since I was diagnosed over 2 years ago. If I space them out, my symptoms come back. It will be a good year before I try and space them out again. I use the Hervert and inject 2mg daily. I have been using this for ~5 months now.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Pins and needles 
Some advice please. 
Muscle weakness and Fatigue 
Normal B12 levels?
