90 Days In.

[WIZARD6787]

I decided after consideration of safety and what is known or thought to be true about the treatment of B12 along with my experiences to test my hypothesis that more frequent injections might be superior to other trials I had done. And that no one had any information on increasing frequency that I had come across.

The hypothesis was not the result of finding what works. The last 90 days have been exploring that hypothesis.

I noticed very quickly when I started reading that it was odd that the protocol of EOD 1 mg of hydroxocobalamin was the most robust protocol and was suggested by symptoms and did not tie into established testing. I assumed I would come across the scientific rationale and to date have not. Nor any scientific reason increased frequency has not been tested but seems to be based on the belief injections by anyone other than medical personnel is not blessed.

4 months ago I started a trial of 1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day. Including injections if I woke up in the middle of the night. I spaced the injections a minimum 4 hours apart. My body adjusted which was hard, resulting in weekly improvement.

I did not experience any reversing out as I did when starving my cells of B12 even at 1.5 mg a day twice a day.

I did experience my body adjusting to having more B12 consistently. I could have seen what I experienced as side effects or caused by additives. I did not, based on my experience and critical research I expected that my body was adjusting and it was not side effects or caused by additives. That was born out as the experiences resolved.

I was surprised by how quickly I could get feedback which I attributed to having enough B12 consistently.

Conclusions:

1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day. Is superior to any protocol I have come across or designed except my current one.

1 mg Cyanocobalamin with 1 mg methylcobalamin is equivalent to 1 mg of hydroxocobalamin and 1 mg of methylcobalamin 5 +- a day

2 mg of methylcobalamin 5 +- alone caused too intense healing. I choose to consider that an upper limit for now.

Having found comfort in having an upper limit I chose to find my lower limit without taking the 6 mg Adenosylcobalamin SL I have taken for years. It was also in preparation to do a trial with injecting Adenosylcobalamin.

I established a lower limit to my satisfaction of 1 mg of B12 4 times a day.

After trying for 2 years I found a source of pharmaceutical grade adenosylcobalamin to mix with saline.

I choose not to share my source. It is a case of risk to me outweighing any potential benefit to the general good. That is absolute at this time.

Conclusion: Current trial of .75 mg of Adenosylcobalamin with .75 mg of Methylcobalamin. 3 times a day is superior to any other protocol I have tried or read about.

I will not be surprised if further trials show that methylcobalamin in the correct amount and frequency will be superior or equivalent to my current protocol. Or if 4 times a day utilizing my current trial is superior once my body heals more.

Have no training in the medical field. Am not claiming to be an expert. I am glad not to be in pain and suffer less. I am still ill. Not as ill as I was 8 days ago. The last 8 days have been difficult as my body adjusts and heals.

It is possible that why I am ill is from not having correct treatment until 8 weeks ago and I need to recover from those three years of exploration and discovery.

The most drastic improvement is that my digestive system which is affected by peripheral nephropathy has at least for the time being normalized.

Other than taking a probiotic in the morning I chose to solve my issues with B12 rather than start investigating other causes or solutions to my digestive system. Other than some home remedies like eating cheese when I had loose bowels.

I was diagnosed with gastritis but reviewed that diagnosis and found it was not valid and given to me only as the results of the PA test. I stopped that medication. No ethical diagnosis was made.

I did experience urinating more as my body adjusted to the changes in protocol. That seems to be resolved. Note: It is known that peripheral nephropathy will cause frequent urination.

[Orchard33]

Thanks for sharing your personal protocol. I also have found that my digestive issues have improved since SI'ing EOD with Pascoe hydroxoc. I can now tolerate some gluten, it seems.

[WIZARD6787 in reply to Orchard33]

You are most welcome. It is a work in progress. I have decided to go from 3 to 4 times a day.

[Wwwdot in reply to Orchard33]

Hi Wiz and Orchard

That’s brilliant feedback from you both!

My gut issues have improved dramatically since I increased my B12 frequency but I also changed my diet dramatically and I think the combined effect has accelerated the healing and recovery. I reduced potential inflammatory foods whilst increasing B12 and supportive gut foods like pre and probiotics and lots of leafy greens.

I was filling in a form for a functional medicine consultation and I have also realised that I no longer crave anything sugary like I used to. In fact quite the opposite I am back to how I used to be before all this began which was preferring savoury food over deserts. My staple snack is an unpasturised cheese with a sour dough cracker - yum!

🤗🤗🤗

[Hockey_player]

You said: Current trial of .75 mg of Adenosylcobalamin with .75 mg of Methylcobalamin. 3 times a day is superior to any other protocol I have tried or read about.

Do you mix them together or inject them separately?

My initial symptom for the B12 deficiency was loose bowels. Fatigue and tingling toes came later. I find cream of wheat helps me to stabilize that, but if someone has a problem with wheat I could see that making it worse.

It's good to hear you are continuing your healing! At some point maybe you will be so much better that it is hard to gauge the differences in treatments. I hope you make a complete recovery!

[WIZARD6787 in reply to Hockey_player]

Separate injections. I inject one in my leg and one in my thigh. Spread it around in my body. It is not crazy if it works. 🙂 I have zero confidence it makes any difference. I inject both at the same time for convince and to keep things standard for evaluation purposes.

I have not designed my next trial it may be to test if Methylcobalamin alone is as effective as my current trial. If so then I might do a trial of same amount more frequently.

I have found that 1 mg per injection site is the most I can inject without sometimes experiencing soreness. 6 injections is a lot of holes in my body.

I would not mix forms as the two compounds might have interactions and change the properties of the compounded liquid. I had some angst about mixing them in my body that I had to overcome.

>>At some point maybe you will be so much better that it is hard to gauge the differences in treatments.

My goal is to increase amounts/frequency and have it make no difference then that will mean I have it right. We will see.

>>I hope you make a complete recovery!

That is my goal. My whole life I have had awful cramps and have not had one in the last two years.

Do you know the cause of cramps? I will tell you. The cause is unknown, only what is thought to cause them. 🙂

I am changing my frequency to 4 injections a day as my body seems to have stabilized from the current trial. What has happened before seems to be my body heals and then I start to do more and need or can handle an increase.

Having an upper limit of B12 at least in one point in time is very helpful to me. Not fun experiencing it. At my upper limit my body is too tired from trying to heal and I need more rest and sleep than is sustainable in my current situation.

[qwertystar]

thank you WIZARD you have really inspired me