I'm sure this has been asked before but I can't find it when I search as was just curious for those who SI if they are suffering with symptoms, if there is no upper limit for B12 then why not inject every day as opposed to every other day?
Does anyone SI every day? If I understand it correctly there should be no issue if we just pee out what our bodies don't use.
There isn't really a risk of overdose, but you should be aware of the other dangers of daily injections.
1. Not rotating your injection sites correctly (which really means the muscles) risks damage and overload. You must rotate your injection sites and muscles to ensure they have time to heal. Every other day works for this as it gives at least 2 days for the site (muscle) to recover.
Otherwise you risk injection site issues or muscle damage. And these are real risks.
2. You need to use the correct type and dosage of B12. Hydroxocobalamin, for example, is a depot injection. And that means it's designed to stay in your system for long periods. So taking it every day won't necessarily lead to long term harm but it can (and did) overwhelm my body when I did it. It was too much healing in a short space of time .
So it may depend on where you are with recovery. If you've had loading doses and a few months into it, then daily hydroxo may be OK.
3. You could benefit from a short period of daily to get levels high. And then maintain a lower frequency after 1 week, moving to EOD.
In the end, you need to test what works for you. But you MUST rotate those sites.
I have to inject twice a day, 6 years into treatment. If I skip the evening, I usually start stumbling around or get tingling flareups. One relative of mine does once daily and another does every other day. Just going by symptoms - if EOD, and the non-injection day feels similar to the injection day, then you probably don't need it daily. On the other hand if you find that symptoms return on days you don't inject, then go for it! If you feel you need it daily, then it won't do any harm. I think people just do what's easiest and cheapest. If I didn't have to do it twice daily, I'd love to go to once daily or EOD or even once a week!
Hi jade, In all that time hasn't anybody really taken an interest in helping you progress. Is it like the NHS being batted from Pillar to Post.
After getting my M.P. involved, I can now see how lucky I was in getting one Specialist who sent me here there and everywhere, bone marrow, nerve studies , endo etc, but at the end he collated all the information. So a case of tick box tick box under one roof. Provided you got on with the specialist far better.
Some times you just need one interested specialist to take on the mammoth task.
Unfortunately no. I've been to too many endos to count (for other reasons), several GPs, several internists (you'd think *they* would know), two gastroenterologists, one neurologist. At best it was no interest, and at worst, I kept getting told that too much B12 would kill me. 🤨 I got literally yelled at by several. The gastro I saw last week was more open, but even then he didn't really provide any help.
Eventually, our ND - which I had hadn't seen since pre-B12 times - took an interest in both mine and my family's situation. Last week we were discussing why I need to inject so frequently, what the root cause could be, etc. She's willing to prescribe as much as needed, and is also interested in trying to find root causes! She's the best I've seen so far, but of course NDs are sometimes dismissed as quacks, unfortunately. I should have probably followed up with a different neurologist but I just didn't have it in me. And then since SI was working, I just gave up getting any help from medical professionals.
Makes me sad to think about those people who are unable to fend for themselves. I'm really glad you were able to find a specialist, thanks to your MP! You're quite right, just takes 1 MD to take interest and push others. The moral of the story is: perseverance! ☺️ Hope you and your husband are both continuing to improve.
Hubby 6 months in and recovering quite well, 1st physio this week through his specialist, at least they will know his ailment. He even now asks for Injection !!,
I am so pleased that you have found someone interested .... and looking at the root of the problem.
Happypensioner successfully found someone interested In her case.
One dedicated person and your lives could change for the better.
Best wishes
Woo hoo very glad to hear it! 🙌
Thank you, I am too! Especially someone - for once - interested in root causes. ☺️
I'm very happy for Happypensioner as well! I actually need to reply to their recent thread, am just a bit behind on the forum.
Take care x
Thank you Jade I’m happy for you, theyre quacks with a heart that’s the difference.xx
Thank you Sallyanni you’ve such a big heart xx
Hi, it's a similar situation for me, I SI about 4/5 times a week (if I try less the fatigue and other symptoms creep back) .I did SI every day for two years when recovering with no side effects.
You probably noticed that in this wide-ranging discussion by intelligent, observant people, no one pointed to a research basis of response. That's because you can search the medical databases from top to bottom and side to side, and you will find nothing except poor-quality studies on treatment of B12 deficiency. Go to scholar.google.com. , a database search engine, and search "B12 deficiency treatment review" for review articles on B12 treatment, and you will find that every single review paper will conclude that high-quality studies on the topic do not exist. Hence, we are forced to resort to hypothesis and anecdotal experience. Thank the Lord for this discussion group, where we are able to find on a daily basis high-quality thinking on which to base our individual treatment decisions.
This is all new to me and this is my first time coming into this forum. I too have this question. Can I inject every day? Something that happened to me, my doctor started me on once a week injections for 3 weeks, I started having abdominal duscomfort. Then I was going to go to once a month by my doctor. I asked is that because that's all my insurance will cover? They never really answered me, but I informed my doctor that I ordered my own B12 and sent them all the info. They helped me get injectable saline by prescription and I gave myself one injection everyday for 4 days. I experienced some pretty bad abdominal pain and right side pain under my ribs so my doctor asked me to only do it once a week. So, last week I didn't not inject until yesterday. My abdominal pain has seemed to lessen, but it's not gone completely. We both felt my pain was my body kind of freaking out because it went from virtually no b12 to 0.03 daily. He thought perhaps my liver could be a little overloaded. That's my experience but I just started 5 weeks ago. So I really am just learning about all of this. I do have some other underlying issues besides, PA. Some of which could be and probably are from, or exasperated by going so long undiagnosed. Good luck to you.
Hi EllaNore and welcome to the forum! 
I suggest you copy/paste your message into a new post of your own. As you can see we all missed your reply, which tends to happen when it's inside a post that already has lots of replies.
Yes no problem to inject every day, but I can't really say much about the abdominal pain. Others might have some ideas. B12 shouldn't stress your liver or kidneys unless you have an underlying problem with them - and even then i think it's mainly the kidneys that are affected, not liver (not 100% sure though).
Thank you Skyrocket123. I will keep the new post in mind for next time. 🙂
Hi. I'm just wondering if you take any supliments along side the b12. Such mixed reviews on how b12 needs extra suppliments to work ?
Daily b12 injections 
Switching from EOD to daily injections
Is is possible to take daily injections of B12 for too long a period?
Self injection update - as promised
