How high fat diet and exercise can affect myelin sheaths production by oligodendrocytes while the person is on high dose of B12 vitamin l

[Hamayeshguy]

I'm wondering how to get our damaged nerves get repaired faster by oligodendrocytes which are responsible in most vertebrates for production of damaged myelin sheaths. Based on Mayo clinic research high fat diet and exercise catalyzes this repair process but saturated fat and sugar damage this process. So what kind of high fat diet and exercise help us our axon myelin sheaths get produced faster. Dies it apply for all axons or just brain axons. Anybody knows anything about it?

[VellBlue]

Hi Hamayeshguy, can you share that research. Thanks.

[Hamayeshguy in reply to VellBlue]

mayoclinic.org/medical-prof...

[VellBlue in reply to Hamayeshguy]

Thanks.

I have noticed I seem to do better when I eat more fat.

[Hamayeshguy in reply to Hamayeshguy]

More detailed research for oligodendrocytes high saturated fat and exercisencbi.nlm.nih.gov/pmc/articl...

[Hamayeshguy in reply to Hamayeshguy]

For Schwann cells I found following research which hints the same high fat diet for repair of axons in PNS

sciencedirect.com/science/a...

[Hamayeshguy in reply to Hamayeshguy]

Some researchs also hinting for DHA intake. Anybody has experience with that?

[bookish]

Really interesting and thanks for posting. Just looking briefly at the reports (mayoclinic.org/medical-prof...

and sciencedirect.com/science/a...) it seems that the fat used was 'from milk and corn oil fat'. Not surprised that that combination without exercise wasn't beneficial, in fact I'm surprised it was beneficial even with exercise! Fat is emotive and few agree on which are beneficial and which problematic so I won't labour the point, we can all do our own research. I can't tolerate dairy or corn so haven't had either in 4 years. I use extra virgin olive oil, some coconut oil, walnuts, eggs, a little fish, a good vitamin E and A (plus D3 and K2). If I could tolerate, I'd be using grass fed ghee, butter, raw dairy, goat etc. To my understanding, we also need methionine for methylation and myelin. Adding a small amount of methylfolate to my methylcobalamin (no diagnosis) has made considerable difference to me personally - brain function, balance, neuropathy etc. Cheers

[Hamayeshguy in reply to bookish]

It's good idea to have methionine but some fat sources foods you mentioned have saturated fats and also trans fat which based on this search along with sugar have detrimental effect on repair process. I'm just wondering axons outside of brain and spinal cord can get repaired by oligodendrocytes just like is done inside of the brain.

[bookish in reply to Hamayeshguy]

My point was that the quality of the saturated fat mentioned in the research was poor. Personally, I am happy to have some good saturated fat. I avoid trans and excessive PUFA (and sugar). I prefer a mix of unprocessed foods and it suits me better. I cook real food, from scratch, so have no additives etc that I can avoid. I don't know the answer to your question, sorry. Poor methylation will affect oligodendrocytes nature.com/articles/s41598-... and pubmed.ncbi.nlm.nih.gov/319...

[Hamayeshguy in reply to bookish]

Sorry my apology there is one more research by the same group regarding Mon saturated fat and I supposed you have read too.

[bookish in reply to Hamayeshguy]

No, I haven't seen that. I'm glad they did a comparison and hope that they used less inflammatory fats. Hardly surprising that the ones they used above had a detrimental effect on repair and would have been interesting to see the difference had they used more generally regarded 'useful' fats. You wonder why they didn't. It makes sense that exercise is beneficial, of course. From my quick reading it does seem that even with their yucky fats, there was still some benefit to fat alone (causing compensatory increased expression) and they also talk of either exercise or saturated fat having the potential to promote new myelin, so even in their context and using this type of fat, it still wasn't clear cut as 'all bad'. Datis Kharrazian's book 'Why Isn't My Brain Working' is a good read, if you are so inclined. Best wishes

[Narwhal10 in reply to bookish]

Great book ! 😊

[charks]

Thank you for that article. It was very interesting.

When I found out I had PA I was also diagnosed with diabetes type 2 and celiac disease. For the past year I have been researching nutrition and trying to work out my best diet. Most nutritional clinical studies are now finding out that the idea that fat is bad for you is completely wrong. That the vast amounts of low fat foods sold are actually helping us get fat. That fat doesn’t cause cholesterol but carbohydrates do. So I eat a lot of animal fat, protein and vegetables but try and avoid carbohydrates and sugar as much as possible. I also exercise twice daily and go for 4 mile walks at least twice a week. My regime has reversed my diabetes type 2. At my last blood test my cholesterol count was very low.

I appear to have been inadvertently following the regime outlined in the article. Which is maybe why I feel so well. 12 months ago I was a physical mess. Now all my major symptoms have gone.

[Nackapan in reply to charks]

Thats good to hear. We'll done.Tired reducing 'bad fats' I sways eat well apart from earning very poorly if its not done for me.

I tried for 4 months . Xsnt exercises ljje you though.

I list over half s stone which j didn't need to.

Got a very dry itchy scalp.

And my cholesterol total figure csnd fien but the all important ratio went up??

I eat mire fats now ad I believe I need them.

Loads od avocados, vegetables. Have bought butter . Use olive oil anyhow

Skwats have little amounts of lean meat. Loads if homegrown veg snd fruits.

Pulses ect.

Pirtife every morning.

Less bread.

Will see what hspirnd next blood test?

Before that j wad eating more liver ect hoping tk get more b12 .

Not very goid with fish ad hydt gives ne nausea. Never have liked it really fo halesowen though. With lots if cider vinegar

Never did stop eating eggs .

I've put the half stone back on.

Symotons unchdged really. Csnt seem yo walk far as my head hurts . Not my kegs! ??

Great it all paid off for you

[bookish in reply to charks]

I'm glad that you are doing well. Absolutely agree about the fat, carbs, sugar. You don't say how low your 'very low' cholesterol is, but I'd be keeping an eye that it doesn't go too low, which may cause or contribute to other problems. Cheers

[charks in reply to bookish]

Many thanks for your concern but my good cholesterol (hdl) is over 2.

[Narwhal10 in reply to charks]

Well done charks, Great to hear your main symptoms are gone.

[charks]

Thank you. Still having problems with frequent peeing though. I have to go ' al fresco' at least twice when I go on my walks. Really annoying. And I still have balance problems. Which make the 'al fresco' peeing quite dangerous.

[Hamayeshguy in reply to charks]

Focus on blood circulation improvement rather than just walking. When you focus on that it urges you to walk as soon as you wake up in the morning until late at night then try to add muscle stretching and some muscle resisting exercises like push-up against the wall or bench or sofa and as well some half Scott and so on. You'd see in ten days most of your symptoms will go away. Gradually increase intensity which may take one month or two months untill you reach your peak

[charks]

Thank you for your advice. I forgot to mention that I do resistance training as well. I'm beginning to think I'm stuck with the problem peeing. I know it's caused by my B12D because it came on so suddenly. If it was a bladder/muscle problem it would have been a gradual thing.