Help. Methylcobalamin

[Reemfali]

So I took Methylcobalamin for ten days. I feel so scared because I feel like it’s making me feel so weird and anxious. Help I’m so scared. I have a nine month old and I have responsibilities. What could have happened. Will I ever feel normal again

[YogiGreg]

Hi Reemfali . I found by accident and then trialling in small amounts that I felt worse using Methyl B12. First time was when I was taking Methyl B12 sublinguals whilst also on Hydroxo B12 loading dose injections and couldn't for the life of me figure out why I was getting more unwell and B12 deficiency symptoms were worsening rather than improving, at this time I didn't have a clue there was actually different types of B12 you could take. The pieces only fell into place when doing searches on this forum and found a few posts that talked about how some people react to Methyl B12 - for me I got really anxious and jittery, panicky, irritable, etc. So as a trial I stopped taking the Methyl B12 sublinguals as a precaution and about 5 or 6 days later started to improve on just the hydroxo injections. Then unwittingly a month or so later decided to start taking a Vit B multi complex and within a day or 2 started again to get all my B12d symptoms back - again really anxious, panicky, etc. Took a day of scratching me head to figure out the Vit B12 complex was using Methyl Folate and Methyl B12, so stopped taking them and again about a week later the symptoms started easing up. Having touched anything methyl since and feeling way better. Who knows why some of us react to methyl B12 this way, perhaps it was causing me to over-methylate, don't know. I'm not medically trained or a chemist or anything, just know that I can't touch a crumb of it and improved using other types of B12 supplements.

All the best

[Statesideheather]

You WILL feel normal again!

Methyl causes me to feel.uncomfortable as well. I take a small amount orally in !y B complex and that does well for me. But if I get a methyl.injection or take high doses of it orally, I feel jittery, anxious unwell and like I need B12.

Hydroxocobalamin shots, unfortunately had me feeling the same.

So I do cyano injections and small amount of methyl and adenosylcobalmin orally, as it's in my B complexion.

You will feel better. It's a lot of trial and error.

Good luck! 😊

[deniseinmilden]

Please go to the Drs / hospital and get the B12 injections you need.

Don't mess about.

[fbirder]

INjecting methylcobalamin made me feel exactly the same. So bad that I only did it the once and gave away the other ampoules. Went back to jmy hydroxocobalamin anf had no problems.

[Reemfali in reply to fbirder]

Thank you all for taking the time to respond to me. It really helps to know that I am not alone. I was wondering how long did it take until you felt absolutely normal again. Not like I’m living in a dream. Derealisation etc

[MoKayD]

I took liquid methylcobalamin and felt awful, anxious, depressed, jittery. I'll never take that again

[Yoyodyne]

I started Methyl-B12 four months ago. My doctor's firm directions were to start one tablet a week for a week, then two for a week, then every other day for a week, then daily, otherwise I'd end up like you describe, as he'd patients who didn't and it took them month(s) to get sorted out. Same with methyl folate. I was quite anxious my first week as well, so extended his one-week increment intervals to two weeks, and was okay. I'm now using both daily, and am looking into increasing methyl folate as it has, for me, a pronounced beneficial effect in reducing fatigue and increasing mental alertness. Much more than B12 but again, for me. Do speak to your doctor.

[Reemfali in reply to Yoyodyne]

Omg makes so much sense. Thank you for this !

[Reemfali in reply to Yoyodyne]

If you don’t mind what clinic does your doctor work at. Is he based in the Uk ?

[Yoyodyne in reply to Reemfali]

'Fraid not. [Edited by admin to remove names of medical practitioners in line with forum rules]

As for different forms of B12, all three are available as oral and/or sublingual tablets. These work for me, so I don't bother with injections. Some people actually do have methylation deficiency, which Dr. XX suspected in my case, and is why he explicitly recommended methyl-cobalamin and methyl-folate. TMG (tri-methyl-glycine) is also frequently used in conjunction. I'm happy with my results.

I also supplement D3. Heed Ryaan's advice below. Folate deficiency can be insidious, and have tragic consequences for pregnant women. I found this site from

nhsinform.scot/illnesses-an...

[Reemfali in reply to Yoyodyne]

Thank you for all the valuable information. I wish I was in CA .. lol

[Yoyodyne in reply to Reemfali]

You're welcome. But there is one thing nagging at me. How long have you experienced whatever symptoms led you to B12 supplementation? Not that you mightn't need it, but you mentioned a baby which suggests you might possibly have several dietary deficiencies to make up for. Omega-3 EFAs are a classic, but hardly the only. You might discuss the possibility with your doctor.

[Reemfali in reply to Yoyodyne]

Hi so the symptoms only started about a month ago

[Reemfali in reply to Reemfali]

I started having burning sensations in my legs. Feeling of being disoriented and funny eye sensations. That’s what led me to b12 supplementation

[Yoyodyne in reply to Reemfali]

I'm not a doctor, Reemfali, and you need one. Or several until you find one who can identify your problems. I haven't asked what other medications you might be taking, as I wouldn't know what to do with them. But your symptoms, while possibly consistent with vitamin and or mineral deficiency (Ca, Mg, Zn, etc), might also be consistent with drug reactions or interaction. Or possibly allergies. Expand your curiosity, google around and look for side effects. Several years ago I had a very bad reaction to an anti-depressant that was "usually quite well tolerated", whose side effects for me were dizziness / loss of balance and peripheral edema and neuropathy -- numbness and tingling in my feet. I made the association on my own, together with internet "research" -- I use the term loosely -- that confirmed Wellbutrin can indeed sometimes do these. ("But they're so rare!") Withdrawal triggered extreme fatigue, which methyl folate and B12 have helped considerably. I take them orally, but again my doctor made a DNA test that suggested I might have problems with methylation. Most people do not, particularly younger people.

I recently tried Duloxetine for the neuropathy and it did help. But it also caused markedly increased dizziness, so I stopped after only a few days. Fortunately the dizziness increase was short lived, and the neuropathy improvement persists. I still have problems with both, but I do have hope, and hope you do as well.

[Gambit62 Administrator in reply to Yoyodyne]

Yoyodyne - please note I have edited your post to remove reference to specific medical practitioners in line with forum rules.

[Yoyodyne in reply to Gambit62]

Thanks!

[Ryaan]

I think yogigregs advice should do the job. Apart from that I would get a blood test for Folate, Ferritin and Vitamin D as these 3 if low cause problems and some similar symptoms as B12 deficiency.

In UK nearly all people use Hydroxocobalamin as I think it’s the only licensed injectable and works just as well as methycobalamin and is actually a more stable form of B12 as Methylcobalamin can get damaged by light and Hydroxo injections don’t.

I hope you find the solution and don’t worry you will get better it will just take a little time.

Try stopping the Methyl form and get Hydroxo or Cyannocobalamin and see how that goes.

[Reemfali in reply to Ryaan]

Hi

Does anyone know how long you should retest for vitamin b12 deficiency ?

I mean after taking b12 vitamins for a while when can I retreat for accurate results ?

[Gambit62 Administrator in reply to Ryaan]

Ryaan. All forms of B12 used medically are sensitive to light. Injectable methylcobalamin is more susceptible to temperature than hydroxo and cyano.