Hello, hoping for a little guidance/information please. My 3 year old grandson recently had a blood test that came back with some 'abnormal results' (doctor's description not ours). Therefore, grandson is waiting to see a pediatrician. We are in a sort of limbo while we wait for the appointment and have turned to google for some answers. Not a good idea really, but one of the possibilities thrown up was pernicious anaemia. Not expecting a diagnosis here, but just wonder can anyone make sense of these blood results. All help/guidance gratefully received. These are the 'abnormal' results as they were conveyed to us by letter. Thank you.
High vitamin B12 (1226 ng/L)
Low haemoglobin (96 g/L)
Low serum ferritin (6 ng/mL)
High total protein (81 g/L)
High plasma lactate (6.05 mmol/L
Thyroid function, U&E's, and the rest of the liver function tests are reported normal.
Could this be pernicious anaemia?
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Ryansdaughter
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I’m sorry to hear that your grandson’s blood tests have come back with some ‘abnormal results’.
Pernicious anaemia is usually characterised by low vitamin B12 and so in my (non-medical) opinion I don’t think this is what the results point to. I suspect that the low haemoglobin and ferritin may be pointing to iron deficiency anaemia however.
I’m sorry that I don’t have enough knowledge to comment on why B12 might be high nor on the other two high results.
Good luck and I hope your grandson is soon well again.
One of the links in the Pinned Posts ( to the right of your post on a computer screen, or below your post on a phone) is to the The Dutch website "Vitamin B12 deficiency in children"
It contains some useful information on symptoms of B12 deficiency in children, and how normal values for total serum B12 change with age. The values are all in pmol/L. Multiply ng/L by 0.738 to get pmol/L. 1226 ng/L is equal to 905 pmol/L.
the high B12 doesn't look like PA - which is an absorption problem -
The article that Martin_12 linked to mentions genetic problems that would lead to insufficient B12 being available in your cells for them to be able to run all the processes they need. However, the items that have been flagged as high aren't items that are generally associated with process using B12 not running properly. The problem highlighted would have had consequences from day one so if the problems have developed recently then it would indicate that something else is going on.
Hello, to me the high b12 and high lactate might indicate a thiamine deficiency. Dr Derrick Lonsdale is a retired pediatrician who has done extensive research about thiamine deficiency. You should look him up and read his articles and see if you feel it could be it. Best of luck
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