Questions for the hive mind. Have been on 3 monthly b12 jabs for a few years now. (I was 109 pmol/L at diagnosis) And despite initial positive response to the first few loading jabs, since then (on quarterly injections) I have gotten steadily worse. More fatigue. Neuropathy. Mental fog etc. One thing I did not know until recently was the importance of having optimal levels of folate and iron in order for the b12 to do it's thing. I am (and have been for a long time) severely deficient in iron and my folate is always at the very baseline or the range.(my epilepsy drugs are known to mess with folate metabolism) My serum b12 remains high even at the end of the 3 months. Always >1500 pmol/L Which leads me to wonder whether that injected b12 is sitting in my blood unutilised due to the lack of co factors.
My aim is to try and address my iron and folate levels and see if this breaks what I think may be a "log jam" in my system and give my body what it needs to utilise the b12 I have. (Does this sound like one logical possibilty as to why the injections have not been effective? I know many here SI as much as daily to keep their blood levels up and high. But as mine do not seem to fall below the highest measure even after 3 months, it feels like it's all sitting there waiting to be used if that makes sense?)
I have FINALLY managed to get a one off iron infusion agreed in the next couple of weeks (I won't go into the aggressive fight I have gone through in order to get this). and have an endometrial ablation coming up in the next couple of months. Both obviously with the aim of addressing iron levels.
I have also ordered 5mg methylfolate supplements with a view to addressing my folate levels.
With regard to the need for a B complex alongside....I will post a pic of the supplement I have. But having read about some members experiencing b6 toxicity I want to be sure to avoid that possible complication if I can.
So....b complex....do you take it continuously or am I right in thinking you take it for a couple of months, have a month off, then start taking it again?
Are the levels in the supplement in question (pic in the comments even high enough B6 wise to cause a problem?)
Also assuming the presence of folic acid in the supplement isn't an issue or likely to cause an issue with too much folate (on top of my 5mg methylfolate supplements) as I'll just excrete any I don't need??
Sorry for the long post. Thanks in advance!