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Pernicious Anaemia Society
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B-Complex Plus or Methyl B12?

Can someone help with this decision? i have seen posts recommending Methylcobalamin (Methyl B12) and B-Complex Plus for B12 deficiency. Can someone confirm if the strength of the vitamin B12 in the B-Complex Plus is ok or should i just go with Methylcobalamin (Methyl B12)?

Here are the links

Methylcobalamin (Methyl B12),


B-Complex Plus


1 Reply

Do you have a diagnosed B12 absorption problem? If not what makes you suspect that you need to use a high dose B12?

If you don't have an absorption problem (or a rare genetic condition that affects your ability to process B12) then you really don't need to use high-dose supplements and although B12 isn't toxic using them can cause other problems metabolising B12.

There is a lot of hype about methylcobalamin saying that it is more natural than other forms. Reality is that it is just as man made as other forms of B12. It is a form that is used in your cells but the process of getting B12 from your food/a supplement to your cell involves a number of steps that make this irrelevant - it doesn't require less processing. Additionally there are two forms of B12 that are used in cells - methyl and adenosyl and sometimes people have problems converting methyl to adenosyl.

Methyl B12 is also less stable than hydroxo and cyanocobalamin.

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