Met my significant other 9 years ago. He was anemic at that time with a hgb of 96. He at the age of 28 had been in a car accident and had to have a transfusion way back before he could have surgery. The hemotologist had followed him for the last 12 years as his hgb has declined with time to having transfusions every two weeks. I have done alot of research and he has had 3 bone marrows which showed no cancer just funky bloodwork with high mcv and hct. I started a b12 deficiency crusade as he has chronic gastritis and an inflammed bowel. Drs said b12 is ok at 241. He has history of his family having autoimmune diseases and inflammatory bowel conditions. His mother had pernicious anemia and beared 14 children in 19 years. There is also pernicious anemia in two of his fathers sisters. The dr. Put him on eprex which to me will make only more faulty blood cells. We argued to trial B12 loading doses to see if the anemia would turn around. He feels great other than his low hgb symptoms. Once again his blood has reached 73 and we are on our way for another transfusion tommorrow. Does anyone know how long it would take to turn the anemia picture around after b12 dosing. Also thinking he may be missing the gene to convert the b12 injection doses as they are not active b12. Maybe we should supplement with sublingual methylcobalamin? Any advice or reccomendations are appreciated. We are just not happy to have the bandaid effect without a diagnosis and are willing to trial anything in the meantime.