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Pernicious Anaemia Society
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HydroxoB12 hydrochloride vs acetate

I ordered some hydroxoB12 through my pharmacist and he sourced Hydroxocobalamin hydrochloride from the Netherlands. The German B12 on the other hand is Hydroxocobalamin acetate. An online search doesn't reveal much information about the hydrochloride version - does anyone know more about it and why it might be preferred or not? Interestingly, the box says to store it in the fridge, whereas the acetate version can be stored at room temp.

In any case the dutch b12 comes in 2mL solutions and I'm finding that I prefer the rotexmedica 1mL ampoules. Quicker to inject and no difference in stinging/burning (if anything the 1mL solution seems to sting less).

4 Replies

They will, to all extents and purposes, be identical. It's just a way of identifying the excipients used for pH balance. Some (most) like to use acetic acid and others like to use hydrochloric acid. Once it gets into the body the results will be the same.

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Fantastic, thank you for the explanation! I suppose I will not have to worry about any potential allergic reaction? Or is that always a possibility when using a new preparation?

Actually while I have you here ;) (or whoever knows the answer to this) if you don't mind another related question --- if I've only ever use hydroxyb12, is there also a possibility of an allergic reaction to cyanob12? At some point I want to try some cyano just to compare its effectiveness to the hydroxy, but was wondering if again I should do it under the supervision of a medical specialist due to risk of an allergic reaction (since i'm doing SI). Or is the main concern a reaction to the cobalamin? Sorry if my question/wording was convoluted, I hope my question is clear. Thanks!


You shouldn't have a reaction to hydrochloric acid. In solution it completely dissociates into H+ and Cl- ions. You'd get the same from salt and vinegar.

Human bodies seem capable of reacting badly to anything, so I wouldn't be surprised if a reaction to cyanocobalamin and not hydroxocobalamin was a possibility, albeit a remote possibility.


oh sheesh, obviously... thx :)


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