Hi. My daughters B12 went down to 74 range (180-900). Once your reserves have gone so low are you able to restore them? After having loading injections twice within a year her level was still only 345 and that was with supplementing. She is still supplementing but am seriously considering self injections as she seems to be deteriorating. The doctors will not give her any more B12 as they are saying that its her depression which is causing the extreme exhaustion and her levels are in range now so its not the cause. They don't believe her when she says that she can't stay awake , can't concentrate to read, or that showering exhausts her. All she does day-in, day-out is sleep, get up for breakfast then sleep, then unless I wake her she will not wake up again till dinner time. She does eat very healthily but even though she's putting in food which is good quality she never feels energised. She takes loads of supplements in the hope that they will boost her but nothing seems to be helping. The antidepressants did absolutely nothing for her when she was on them for 6 years, neither did the CBT or the art therapy, music therapy etc...I am at a loss as to what to do next!