That's a mouthful right there!
I have what is known as a compound heterozygous mthfr mutation. Basically this means that I received one faulty copy of two different genes that deal with methylation. In a practical sense, it affects enzyme production that breaks down folate and homocysteine and it's estimated that this mutation combination affects function by 50%.
I had some blood tests done in August 2014, which showed a B12 level of 374, ferritin of 8, and folate of 4.8. Not stellar, but I was still upright.
I was prescribed ferrous fumarate for the ferritin problem but the other two were 'normal' so no action. I decided to supplement 1000mcg methylcobalamin per day and take a B complex too.
My question is what levels of B12 would you expect to see in someone who takes 1000mcg per day? I would imagine that they'd be quite high (1000+?) but my last B12 test showed a level of 750, having stopped the supplements 2-3 weeks beforehand. I can't help the feeling that if I stopped for longer I'd be back in under 500 territory...
I appreciate that this is a 'piece of string' question but I'd be interested to know what you think.