CA125 rising following first chemo

[Ghazala1]

Hi. My Ca125 has gone up from 1200 to 1600 after my first session of chemo of Carboplatin and Taxol. I’ve just had my second session yesterday and my oncologist said to wait to see him f it comes down after this one.

I am worried it’s not working.

Has this happened to anyone else?

Any advice would be welcome

Thank you x

[Lyndy]

Sometimes it does happen that ca125 goes up initially. Just take it one day at a time and fingers crossed you will see a change after chemo 2 xx

[Ghazala1 in reply to Lyndy]

Thank you. I really hope so x

[MPee123]

Yes it happened to me - mine went from 2700 to 5400 after the first chemo then it started to come down quickly (I only had the carbo bit for first treatment and they added taxol for the second round) x good luck 🙏🏻❤️🙏🏻

[Ghazala1 in reply to MPee123]

Thank you. That’s helped putting my mind at rest. Am I right in thinking it came down after the second session?

[MPee123 in reply to Ghazala1]

Yes that’s right 😁

[Inguc_is]

My moms ca before firs chemo was 220 but after 1st 230, doctor said that probably it is because bad cells die and he was true after second it goes down to 116

[Ruebacelle]

Give it time it may take all 6 chemos. Dont worry. Hugs from paris

[Ghazala1 in reply to Ruebacelle]

Thank you x

[Lookingahead]

Yes it happened to me — I was told as the cancer cells die after the first chemo they release the Ca125 protein . It’s known as tumour flair . It came down after the second and subsequent treatments —- hope that is reassuring x x

[Ghazala1 in reply to Lookingahead]

Thank you for the reassurance x

[Clipper15]

It happened to me. Came down on 2nd or 3rd can remember which. Just to give you hope, Ive just completed six months on taxol and my CA125 has gone from 1000 to 51 ! All tumours have shrunk and are stable. Just going too monitor me with bloods for now. Good luck to you. I wont say dont worry as its impossible not to but be kind to yourself. Let us know how you get on. Xxx

[Ghazala1 in reply to Clipper15]

Thank you for putting my mind at rest x

[Iside]

Hi, I too used to put great store on CA125 results but now don’t even bother to check them as in my case have found them unreliable. It’s more how I am feeling that is important to me now after 3.5 years of fighting this beast. Iside X

[KeepMoving2]

Echoing all the other replies - docs told me to expect tumor markers to initially go up as cancer cells die off. Be patient but keep tracking the numbers.

[Ghazala1 in reply to KeepMoving2]

Thank you x