Mirasol trial

[Millie-c]

I have been on this forum for over 5 years now. I feel extremely fortunate to still be checking in to read posts although I haven’t posted in forever. I have just had 3 rounds of carbo caelyx for my second recurrence and it’s not working. My options are weekly taxol or a trial? The mirasol trial has been mentioned but when I put it in the search bar on here to see real experiences of the drug IMGN853 / MIRV / Mirvetuximab Soravtansine there is not really any information. I believe the drug was used in the FORWARD 1 trial, and a trial called SORAYA ?? The tumours have to have a folate receptor alpha. My question I suppose is do any of you ladies on here have any experience or tips from being on this drug?? I have done the google search, but it doesn’t give me any real life experience information?? Love and hugs to all of you on here. I don’t know how I would have managed without you all.

Mandy, xx

[JustKBO]

Im sorry I’ve never heard of it but I am interested in any new drug. When I recur again it will be my 2nd too and who knows what they will give me so I hope that if you decide on the trial you let us know how you get on. Good luck Maria.

[Millie-c in reply to JustKBO]

Thanks for your reply Maria. I’m certainly interested in the drug, it is a phase 3 trial so quite a bit of evidence to say better progression free survival and more tolerable side effects compared to chemotherapy. It’s not definite it would be the new drug that is given as it is a randomised process but weekly chemo is my next option anyway so not much of a gamble to be fair. I will keep you posted. Xxx

[RomanZ]

Hi Mandy,

Sorry, no real life experience but I've read about Mirvatuximab over the past couple of years. The drug is designed to bind to folate receptors which are commonly over expressed on ovarian cancer cells. It then delivers the chemo. The drug works best with women that have high folate expression. I believe as many as 50% of women with ovarian cancer have high folate expression.

A recent trial combined Mirvatuximab with Avastin in platinum agnostic women, 50% were platinum sensitive and the other 50% were platinum resistant. The results were pretty good. Platinum resistant women with high folate expression had a 59% objective response rate (ORR) and 97% of patients demonstrated tumour burden reduction.

I tried to get my mum onto this trial as her folate expression test came back high.

Here is the link to the trial results:

onclive.com/view/mirvetuxim...

All the best,

Roman

[Millie-c in reply to RomanZ]

Thanks for the information Roman, sounds very positive. I find it amazing that all these trials are happening and I have such hopes in longer progression free life for ladies in the future. If I can be a small part of that, it gives me some purpose in the fight.

[Gardengirl60x]

Hi Mandy I was invited to take part in the Mirasol trial but unfortunately my folate receptor test came back negative. I was told it was as high failure rate for having the required receptors but it's well worth a try. There are two arms to the trial the other one in my case was weekly taxol.Hope you get on it. Please keep us posted with how you get on . Kath x

[Millie-c]

Hi Kath, sorry to hear you didn’t get on the trial. What were the other options for you? Did you do weekly taxol?