Parp inhibitors trial

[SueLR]

Does anyone have any experience of the current ARIEL2 trial of parp inhibitors?

My oncologist has offered to refer me as it is possible my second remission is ending, and I have read the information on here and other websites, but would love to hear from anyone who is on the trial to help me make a decision.

Many thanks.

Sue

[TrishLey]

Hi Sue,

I am not on any trails but I know a lot of ladies on the America sites speak frequently about PARP Inhibitors and Trials they are on. I looked up ARIEL2 and from what I can see they are doing it in the USA too if no one here is on the trial and can give you their first hand experience - clinicaltrials.gov/show/NCT... .

Might be a option for you to check out the American Site and ask there. I hope it helps in some small way.

xxx

Trish

This is the American Site: Team Inspire <[e-mail]>

[Hidden]

I am on a phase 3 trial called SOLO2 which is for olaparib as a maintenance treatment for women who are BRCA positive, have had at least 2 lines of prior treatment and are still platinum sensitive on most recent chemo. I appreciate that the drug is different but I am happy to share my experience if it would be useful.

[sharonforce]

Hi Sue

I don't have experience of the Ariel trial but I do have experience of other parp inhibitor trials. Two years ago I was on the BioMarin BMN673 phase 1 parp inhibitor trial for 11 months. Six weeks ago I started on a different parp inhibitor trial, Olaparib in combination with an AKT inhibitor. Both have been/are very tolerable for me. Happy to answer any questions.

Best wishes

Sharon

[Lovis]

Hello, Are PARP Inhibitors just for those with the BRCA gene? Lovis

[Hidden]

I don't think so. I'm BRCA negative, but my onc has mentioned them as a possibility if needed further down the line. I've a feeling I caught a reference to BRCA or BRCA like in one of the trial descriptions.....

[thehusband]

I cant offer any insight to the trial but i can say that it is my very strong belief that PARPS are the way forward and i feel it wont be long until they are standard treatment. Good luck on the trial. Laurence

[SueLR]

Thank you all. I've previously been through all the screening for a similar trial, but over about a year when they had places, I wasn't suitable, and when I was, they didn't have places, and it's really put me off getting into all that again. Alstromeria and Sharon, how did you find being on a trial, in terms of time commitments and interventions, and do you think it was worth it?

It's also being offered as an alternative to chemo and I'm not sure whether to trust it above something which is brutal, but works.

Of course my scan could come back fine and I won't have to think about all this. Umm.

Thanks again

Sue

[Hidden]

There is no doubt that you spend a lot more time in hospital on a clinical trial, though how much more depends on the trial. On my first trial I attended clinic every 6 weeks, but there were no additional interventions over the usual screening tests. On my current trial, there were weekly clinics for a month at the start, since then every 4 weeks, plus a CT scan every 12 weeks. So, quite a big commitment. Personally, I prefer trial clinics - I always see a consultant, don't have to wait very long to be seen + there just seems to be more time and attention for me. So, yes, worth it in my opinion.

As to your other point about choosing between standard chemo and a trial - yes, that is tricky. I have not had to make such a decision, as I got the standard treatment anyway - the trial drug was in addition to it.

Let's hope you don't have to make this decision yet - fingers crossed for your scan results xxx

[cmarkd01]

Hi. Can someone tell me if these trials use oral medicaton or are they IV? I ask this because my wife Ingrid cannot take any oral medication due to her acute bowel obstruction. Also, are these trials for high grade or low grade OC? Thanks!

[Hidden]

Cmark both my trials were oral meds. I am high grade, which is fairly typical for BRCA+ ovca. I am pretty sure that my current trial specified a high grade serous diagnosis.