Cyclophosphamide & Niraparib: Hi ladies, It’s been... - OvaCare

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Cyclophosphamide & Niraparib

25 Replies

Hi ladies,

It’s been a tough week for me. After 6 months of Taxol there is no improvement in my tumours. But they have remained stable. I was giving up all hope but today my oncologist said that I’ll be starting new treatment on Monday.

Cyclophosphamide & Niraparib

Has anyone any experience with either? I’ve never even heard of Cyclophosphamide as a chemo infusion.

Anne

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25 Replies
ZenaJ profile image
ZenaJ

I haven't heard of it but it's good news that they're starting a new treatment. We all hope it's going to be good news. xx

in reply toZenaJ

Thank you for that kind reply, Zena.

Anne xxx

Tvam profile image
Tvam

I've certainly heard of cyclophosphamide for treatment of other cancers, it's disappointing that there's no change after the taxol but good that the tumours haven't increased in size. Best of luck with everything

in reply toTvam

Thank you for your kind reply.

Anne xxx

2016Mags profile image
2016Mags

Hi Anne,

I have not heard of cyclophosphamide but I was due to be started on Niraparib after 6 sessions of Taxol and Carboplatin, but I’ve to do a few more sessions 🙄 and then my Oncologist has changed his mind to Avastin again. It’s all very confusing and I wish you luck with your treatment and hope things improve.

Have you done genetic testing, I was so close to qualifying for immunotherapy but it didn’t work out, my Oncologist said it would have been great for me.

Mags xx

in reply to2016Mags

Hi Mags. Thank you for your reply. I have the faulty BRCA1 gene.

That’s extremely frustrating about immunotherapy for you. Is there nothing you can do to get it? It’s hard to believe that you can’t access what you need. It hasn’t been mentioned to me as an option so far.

Anne xxx

in reply to

thanks for thinking of me.

End stages here. Liver failure.

I wish all of you a better outcome.

Nanfoster profile image
Nanfoster in reply to2016Mags

Hi Anne,

I was on Avastin for one month. One’s blood pressure tends to increase so be sure to monitor it at home. It was stopped for this reason. In the 180’s 190’s best of luck.

21752 profile image
21752

hi, I have been taking olaparib for almost 4 years which is in the same family as Niraparib. I also have gene brca2 .

I know I had to push my oncologist back then to get the drug, I am still in the minority in my area to receive it.

I don’t know where you live , the criteria for receiving drugs varies so much and can be dependent on where you live but I think you will need to push your oncologist a little more. I really do hope you get the treatment you need, keep pushing if you are refused go back again. You will be in my thoughts.

in reply to21752

Thank you very much for your kind reply.

I was on Olaparib for over two years but it stopped working for me. I’m starting Niraparib tonight. Apparently it is a little different so I hope it’ll do something for me.

I’m starting a new chemo infusion tomorrow. It’s Cyclophosphamide. I’m exhausted all the time and not doing too well but hoping for some improvements from the new chemo & Niraparib. I’m BRCA1.

It’s excellent that Olaparib is working for you for so long. That’s very promising for you. I wish you continued success on it.

Anne xxx

21752 profile image
21752 in reply to

Thankyou I hope you do well on niraparib I always think that the longer we hold on something new will come along. Do you mind me asking you if you responded well to platinum chemo, carboplatin etc.

Is there a criteria for being able to take niraparib. My very best wishes to you

Carol.

in reply to21752

I live in Ireland. I don’t know what the criteria are to qualify for it, though.

I respond very well to Carbo. It worked for chemo in 2015 and 2018. I got two infusions of it this time but had a massive anaphylactic shock reaction to it after only 10mls of the third dose. I nearly died so unfortunately it is no longer an option for me. Thank you for asking. I appreciate your interest.

Anne xxx

2016Mags profile image
2016Mags in reply to

Hi Anne, the very same thing happened to me recently with Carboplatin and I also had it in 2016 and 2019, but my oncologist has desensitised it and instead of taking 1 hour for the infusion it now takes 2 1/2 hours, I was able to get through it the last session, my stomach felt sick a few mins in but I took Zofran and was able to take it then, thank God, Having it again today so fingers crossed. I am also in Ireland. Best of luck with your treatment xxx

in reply to2016Mags

Thank you for replying.

It’s brilliant that you can still get Carbo. I’m delighted for you. My consultant doesn’t think it’s an option for me anymore, unfortunately. I had been having the infusion over 2 1/2 hours too. I’ve just finished my first infusion of Cyclophosphamide. I can only hope that it does some good!

I hope the Carbo goes well for you today!

Anne xxx

2016Mags profile image
2016Mags in reply to

Jo Anne. Bad news…had a reaction again this am to carbo so it had to be stopped….no more carbo for me, Hope your treatment works well…let me know how you get on ❤️

in reply to2016Mags

Damn! I’m sorry to hear that. That was distressing for you. I’m sure your consultant will come up with an alternative plan. Sorry you’ve had a tough day.

Anne xxx

in reply to2016Mags

My first infusion of Cyclophosphamide was fine, thank you. Felt nauseous but they gave me Emend.

in reply to2016Mags

I hope you’re doing okay and have a new treatment plan.

Anne

2016Mags profile image
2016Mags

Thanks Anne, I don’t know what the next plan is yet. Like you after months of treatment, and surgery in June, cancer is still there. It’s such a worrying time but great to see on this site that people are doing well and surviving longer than what the outcome was not that long ago. I hope you are coping well on your new treatment and all we can do is stay as positive as possible and keep fighting. xxx

in reply to2016Mags

That’s true re survivors. You’re great!

You do the same about keeping positive and strong.

I hope you have a good Christmas 🎄

Anne xxx

2016Mags profile image
2016Mags in reply to

Hi Anne, I hope you are feeling well and tolerating the new med well. Happy Christmas and I hope you can enjoy the festive season with your family….Margaret

2016Mags profile image
2016Mags

Hi Anne, hope you are keeping well and wondering how you are getting on with your new treatment….Mags

in reply to2016Mags

thanks for thinking of me.

End stages here. Liver failure.

I wish all of you a better outcome.

2016Mags profile image
2016Mags in reply to

God bless you Anne, my prayers are with you ❤️

Lmcn profile image
Lmcn

I’m on Niraparp since June 2022. Only on 100mg daily . I’ve no side effects except being a bit tired . My ca125 is rising but my scans show slight reduction. I’m BRACA neg

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