Rucaparib

[airfemale]

I read all your posts from the other side of the world. I have been fighting this ovarian cancer thing now for year and half. I had stage 3c ,the debulking operation, and then had the first round of chemo, taxol carboplatin, cisplatin ivp port went into remission for 9 months and then the secondaries have started. Second operation tumour off my bladder and lymph nodes removal. I read with great interest your avastin journey and what will be my probable future. My wonderful oncologist has asked me to participate in trial 3 of rucaparib. Does anyone have anything they know about this.

[Lovis]

No, sorry not heard of that one! Lovis x

[goinggaga]

I have no experience of this drug but there is information on the Cancer Research UK website regarding the trial. Don't know if this will help any but wishing you well with your treatment.

Love Wendy x

[thehusband]

Hi......I am sure that plenty of people will come back to you regarding Rucaparib, whilst i have no immediate knowledge of it i just wanted to say that my Wife and I tried to get her onto a trial of this because we both believe that it will have a big part to play in the future of OC treatment.

I think the 'PARIBS' and targetted treatments are going to see many more ladies have successful treatments....i hope so anyway.

Sadly she never managed to get on a trial and eventually lost her fight.....i wish you the best of luck. Laurence

[Hidden]

No I havent heard of it over here in Ireland. I am on Avastin which is a targeted therapy, it does work well in keeping 125 levels down, it is more effective with a chemo drug. Once chemo is finished here, you remain on Avastin, it is working out for me so far. Side effects would be tiredness, feeling a bit down but dont we all feel down with this illness anyhow. The good story is that more treatments are becoming available nd Ovarian Cancer can be managed nowadays. Wishing you the best,

[daisies]

Hi, like most of the others I have not heard of that drug, but as you know a lot of drugs are still in trial basis. My treatment regime was carboplatin & taxol first time round, and the 2nd time round avastin was added and stayed on avastin. Heading in to 3rd time round, beginning tomorrow, and carboplatin, taxoxl & avastin are the regime still, as my wonderful oncologist said "they worked before" and the other drugs are still there is we need to change.

Do let us all know how you get on with the new drug. Our oncologists only recommend drugs for each of us where appropriate

Love Daisies.

[thehusband]

Further to my earlier response the details below are about the phase 2 trial that we tried to get my wife on, she had high grade serous and as far as we know wasnt BRCA - but our Onc didnt think she would be eligible. Anyway i have put this up so anyone interested can see about Rucaparib, there are ongoing other trials for this parp....

A trial looking at a new drug called rucaparib for breast and ovarian cancer, in people with BRCA gene faults (PH2/052)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

This trial is to find out how well a new treatment called rucaparib (also known as CO-338, AG-014699, or PF-01367338) works. The trial is for people with an inherited fault in the BRCA1 or BRCA2 gene who have locally advanced or advanced breast cancer, or advanced ovarian cancer. Women who have serous ovarian cancer that is high grade can take part in the trial even if they do not have a BRCA gene fault. This trial is supported by Cancer Research UK.

Rucaparib is a type of treatment called a PARP-1 inhibitor. This means it blocks an enzyme called PARP-1, which helps damaged cells to repair themselves. PARP stands for poly ADP-ribose polymerase and is found in all cells, including cancer cells.

The cells in your cancer already have problems with repairing cell damage, because of the BRCA gene fault. Doctors hope that if they can stop PARP-1 working, the cancer cells containing BRCA gene faults will not be able to repair themselves and will die. Although PARP-1 will be blocked in all the other cells in your body, these healthy cells are able to repair themselves because they do not have the BRCA gene fault.

Early research in the laboratory has shown that rucaparib can stop cancer cells that have BRCA gene faults from repairing themselves. The aim of this trial is to find out

How well rucaparib works as a treatment for breast and ovarian cancer in people with BRCA gene faults and for high grade serous ovarian cancer without the BRCA gene fault

What the side effects are

What happens to rucaparib inside the body

Recruitment

Start 12/12/2007

End 04/10/2013

Phase

Phase 2