Let me preface this by saying I am in the US, so I take 1mg of folic acid every day. Every US based website I have reviewed said that patients may begin to see improvements within 4-8 weeks, I know I have read on here somewhere between 8 & 12 weeks. I have taken my 4th week of pills this past Saturday, I take 15mg orally. I'm one of the very lucky few who has no side effects to the medicine, I take it at night, wake up the next morning and feel "normal". I was just diagnosed at the beginning of December, and this is the first drug I am on. I was diagnosed very quickly, began having symptoms at the end of September. I had positive rheumatoid factor and negative anti-ccp, I don't know if any of this stuff matters to this conversation, but thought I would throw it in there.
We are having frigid cold temperatures here in the US, yesterday morning it was -15 degrees F (-26 Celsius). And I woke up a little sore, but as the day went on nothing hurt. Usually when I am sleeping it is the worst, my ankles and toes swell up and are sensitive to touch, but last night, no pain. Then this morning, I woke up, no stiffness, and the slightest bit of pain in my thumb (which has never hurt before) but that went away within the hour.
Could it be that the methotrexate is starting to work, or is my RA just playing tricks on me? Either way, I'm going to savor the pain free time.