Well, I'd got myself into a proper tweak over taking mtx. Reading everything I could find, asking others' opinions and having a fair few sleepless nights. Now, I know we are all different and react very differently to the drugs we are given but I took the first dose on Thursday. I took it with my evening meal, drank lashings of water and ginger beer and - nothing. A little queasiness perhaps but nothing significant. I know it's only the first dose, that I could be lucky, that things may change in time but, whooppee, am I relieved!