Yesterday morning I took my 2nd dose of MTX ( 15mg ), I was very fatigued, dizzy and couldn't face food but not sick. I didn't feel like that last week so I wasn't really prepared for it. Is this usual and can I expect it to be even worse next week. I have read that some people take their MTX at bedtime, is this preferable and do you need to eat when taking them. No one has explained it to me other than take once a week and don't drink alcohol. As it took 5 yrs to get diagnosed, several symptoms I put down to other things for yrs such as the awful fatigue I thought it was just with looking after my ill husband and having everything to do within the household ( and I really mean everything ) , so I was wondering if the pain and crunching in my neck is down to RA or could it be something else. I do realise that we can't give medical opinions but I am thinking if anyone else suffers from the same symptoms, or am I just trying to put every ache and pain down to RA, or maybe I am being making mountains out of molehills.