I feel sorry for you all, I was on sulphasalasine 17 years accompanied by diclofenac sodium. it suddenly decided not to work and I went to around 30 crp very stiff and painful. I was put on methotrexate till I reached 20 mg (8) tablets along with the sulphasalasine it didn't touch it. I was allowed to go on humira as the other two tablets were not doing it for me. After my first injection and before my second one two weeks after, I had dropped to 1.7 crp, I know, unbelievable, I have been using this pen every two weeks for around 4 years now and 4 methotrexate as it's said they work together. I have never gone above 3 crp usually 1 or 2( crp (( inflammation test I believe)). I check it after each monthly blood test. I no longer take diclofenac sodium or paracetamol. I must be in remission, I can actually jog if I wanted to, 65, so i probably won't and no fatigue. I don't know if anyone has found this doesn't agree with them, but so far so good for me. It's worth a word with you rheumatologist nurse. I've now, as all is working well, been asked if i'd mind using the pen every three weeks instead of every two. I'll give it a try and see what happens. I have plenty of bone fusing from the previous years but no pain or stiffness. I hope you all find your helpful treatment.