Haven't been posting much but have been following posts and occasionally commenting. Been a bit occupied this year with shoulder op, then had grandkids for a couple of weeks, then sick on and off with severe asthma from chest infections and working and just trying to put one foot in front of the other. Have been on and off enbrel 3 times this year already and now it looks as though it is no longer working for me. I have been back on it after the last break for 6 weeks and I am in so much pain in my feet and ankles I am finding it very hard to walk, my hands are swollen and my fingers are very painful and locking at night and I have to pry them open, my wrists ache all the time. I am so fatigued I have fallen asleep at work a few times, ooops bit embarrassing, and I am now spending every weekend sleeping Saturday away and barely getting up on Sunday to do what I have to. Gave in and called rheumy nurse today who agrees that it sounds like it isn't working and it is 6 more weeks until my appt there so has sent me a script for prednisone to start and if that improves how I am feeling then it will confirm that I have developed antibodies to enbrel and it is no longer working. I feel completely gutted because it took so long to get on to enbrel and I have only been on it about 15 months. I also got off pred late last year finally and lost so much weight and now I will have to go back on it and stack all the weight I lost back on. I really hate this disease and feeling very flat!