Hello - During my 15 year career with rheumatoid arthritis, I have generally annoyed the living crap out of my rheumys, by refusing to take the DMARDs. I did dabble in Methotrexate for a while, but then stopped and started several time. My problem is that I'm prone to anxiety, and the DMARDs scare the living daylights of me. Now, eventually, my body is falling apart after two knee replacements, and so I gave in and took Enbrel. It was okay at first, and certainly brought my inflammation down enormously. However, it also affected my vision severely, giving me double vision and blurry vision. It also makes me very tired and depressed, to the point where I can barely get out of bed all day (this could be attributed to the fact I take a cocktail of other drugs, and they may not get along well together). Also, I have strange pain and lumpy bits on my jaw. I must be an idiot for waiting so long to take the DMARDs, because I think that while none of them are great, they might have worked for me,... and Enbrel must be the drug that's the scariest. Does anyone else take Enbrel ? Are there any side effects ? Thanks so much.... best wishes to everyone.