I suffered with a sore mouth when starting Methotrexate and was told to up my folic acid to one a day except the day I was injecting. That answered the problems until this last week. I have been injecting Enbrel for about six weeks and this week my sore mouth is back. The Enbrel nurse doesn't think it's that and that the Methotrexate is again the culprit. Anyone had the same or any suggestions please?