I just wanted to ask if anyone is on biologic drugs without taking Methotrexate. I inject Enbrel/Etanercept once a week and I'm supposed to be injecting Methotrexate once a week also. I have taken the Methotrexate on and off for the last 3 years. It makes me feel ill......very tired, lethargic and sick. I work full time and I am now in my 3rd year at college in the evenings. I've tried switching around when I inject but I cannot find the right time to feel awful for a couple of times a week. After 2 years of not being able to do any exercise I have just started to try and get back in to it. Not easy but little and often. I have stopped taking the Methotrexate now but I am continuing with the Enbrel. Am I kidding myself or can I actually try and make this work? Pain is bad but feeling ill every week is worse. I would really appreciate your views. I wish this stupid disease would just go away!!!