Hi everyone, haven`t been on here for a while, hope everyone`s doing OK. Anyway, I´ve been taking methotrexate 2.5 mg ( four tablets per week) since April, so far so good. I think I´m very lucky compared to what some people go through on here. However, I just wondered if anyone else has experienced total exhaustion for a day or two each week after taking the pills. I take mine on Mondays, Tuesdays and Wednesdays I´m totally knocked out. Is this normal, does anyone know? Thanks.