Hi everyone, I've been taking MTX tablets 10mg for about a year, but lately I've been skipping most weeks, because of the nausea.. -So next week a nurse is coming to start me on Metoject instead
I'm getting worried now though, having read some posts about side effects from it, like nausea.. I thought the whole point of the injection was that you don't get nausea from it??
My experience is Mtx injections made the nausea less x good luck. If it doesn't help you can try another dmard xx
It’s like any drug really, some people will be ok and others not. I was nauseous for 5 days after whilst on it but lots on here don’t have nausea. You can only try it and see, you’ll probably be fine 😊
i have been on the injections for 11 weeks now after having tablets for a year, the nausea has almost gone, and i no longer get mouth ulcers, the injections are so simple and painless.. i have a phobia of needles but i am able to do mine now without even thinking about it, you'll be just fine 
Thank you Bootoo.. I'm terrified of the effects of the 1st jab though-..how i will feel the next day!!
i have found i still feel wiped out the day after but no nausea so that is a plus,my rheumy nurse said it was probably because my body was getting use to a higher dose, try not to worry too much. I didn't sleep the night before my 1st injection, i worked myself up to the point of sheer panic.. all for nothing, now its just something i do before i go to bed once a week.
Thanks for that Bootoo! that's very reassuring - now i don't feel as scared ! 😊
glad i could help ease your fears
You are less likely to have nausea on injections, it's one of the reasons we can be changed to them. Nearly 50 years after MTX injections were first tried as an alternative route more people stay on them than tablets because side effects are fewer.
Try not to focus on what might not happen. We had a post only recently about a member who had this very problem though she was already on injections, have a read healthunlocked.com/nras/pos...
Many of us do well on them & it pays to remember that in the main only people who are having problems need forums such as ours, those doing well have less so, so you will read of the odd person who's not doing well on something or doesn't help them. Some come back & let us know that the injections eased side effects they had on tablets or more often went.
Also, if it's been a dose problem causing your nausea on tablets, too high a dose, often your MTX can be reduced when we go onto injections because it bypasses the stomach & foes into the blood stream. It happened to me.
So hopefully no more skipping & more control is coming your way, along with the hope you do as well on it as I have, & I've been on injections 9 years.
Thank you for that nomoreheels! - thats an interesting post about the 'anticipatory nausea'- I feel sick before I take the tabs! - Just the thought of them is enough.
Thanks to all of you here, I am starting to feel a bit better about having the jabs now...
Good. I'm pleased. It helps to have that support out there doesn't it?
It certainly does!! - people who understand and all help eachother- Thank you all ! ❤
Really don't worry. I was totally needle phobic from bad experiences as a child, and the idea of swapping to injections was a huge issue for me. Before the first injection I was shaking like a leaf, and terrified. I put it off twice!
But it's totally fine. Follow the nurse's instructions and you won't feel a thing - especially if you are started straight on the pens.
(And no nausea too)
Thank you helixhelix, that's encouraging to hear! Betweem you all, i feel a lot better about it all, thank you!!
I assume you are on Folic Acid?
Hi Vonniesims, yes, the nurse raised it to 10mg per week.. it didn't make much difference, maybe they will raise it more..
The perfect forumla for me is:
MTX jab + 5mg folic acid 6 days a week + taking it easy the day after MTX day = no more nausea for me. Yippee!!
Hi Joy, thank you, sound good plan - I think maybe i should ask my nurse to raise my folic.. I'm on just 2 x 5mg a week..
I was initially told to take 1 x 5mg of folic acid a couple of days after taking my MTX. The Prof said this was to maximize the body's uptake of MTX. But the nausea was horrific so then I was told to increase the folate to twice a week. That did not help ... then 3 and so on till eventually taking folic acid 6 days a week did the trick.
15mg MTX was my tipping point when it came to the nausea.
I dont get nausea but thats me - before I started taking any drugs I phoned the NRAS helpline they are very helpful and they got someone who has been injecting for a while to phone me = I think i spoke twice to this person - i found it helpful - good luck x
Thanks lornaisobel - that's a good idea as well x
Do you take anything to help the nausea? I’m on the same amount of pills but the last couple of months I’ve been really nauseous and doc gave me zofran 4MG to take an hour before methotrexate. Seems to be helping a lot. Good luck. Keep us informed of how it goes.
Interesting.. no, they haven't offered me anything to take for the nausea, just arranged for me to have the injectable instead. That's good to know, thanks Bonnie - I never heard of zofran, I'm glad that its helping you
The Metoject is just great, the nausea is greatly reduced. I’m now 7 weeks into the Metoject 25mg, so far so good. I can’t thank my Rheumy team enough for helping me manage my RA. Wear your ‘positive knicks!’ and you be just fine!!!
Ha ha will do! - Thanks Floralqueens!
🤞🏻😘xx
The injection is so easy to do yourself. I did mine on friday night, Saturday was fine, but Sunday i wanted to sleep all day, very little nausea but just enormous fatigue until 5pm. So we all react differently. Good luck, hope you find it more tolerable than the little yellow perils!! ❤❤❤
That's encouraging - many thanks for that SLEepyhead ! - makes me feel better about it all x 😊
Hi Jimmyx. I was on 25 mg if mtx weekly injections. Yes I did have some nausea but nothing like it was when I was taking oral. Go into it with a good attitude and give it a try. You might be able to deal with the nausea better.
Good luck and let us know how you do.
Thank you so much Edie - you're all so helpful. Tis much appreciated 😀
Biologics vs Mtx injections
MTX Injection update!!!
Mtx injection 
Late post MTX 3rd injections and increased dose
