I got my first Ocrevus infusion yesterday. They started out by giving me oral doses of Tylenol and Benadryl. Then, I got the IV started (took 4 tries!), and they gave me some steroids to help prevent an infusion reaction. After 30 minutes, they started the Ocrevus. I did fine for about the first hour, and then I started breaking out in red itchy patches all over my face, head, chest, back, and right arm. They had to stop the infusion to give me more Benadryl and steroids through the IV. It hit my system really quickly, and I had a bad reaction to that (almost got sick and fainted). It did end up getting rid of the infusion reaction, and I started feeling better after about 1/2 hour. They were then able to finish the infusion. I did get another hot red rash on my cheeks toward the end of the infusion, but it wasn't bad enough to need more meds to help it. Today I'm pretty tired and a little achy. Hopefully I'll feel better tomorrow Also, there was another lady with MS at the infusion center with me who started her first round of Ocrevus and she had no problems at all. My MS specialist said that the people that she has seen getting the infusion (with the exception now of me!) didn't have any infusion reactions. I'll go back in 2 weeks for the next dose. Hopefully that will go better!