advice about danazol

[IZUKI]

when a patient receives Jakavi during 6 months and has lower erythrocytes and hemoglobine and needs blood transfusion. how effective is to receive danazol with Jakavi? Is anyone who receives both?

[hunter5582]

Combining a medication to stimulate erythropoiesis is one of the options. More recently, there is a new JAK inhibitor that has an indication for MF with anemia - momelotinib. This may be prefered depending on your MPN profile and what medications are available on your health care plan/system.

Some of the medications used on combination with Jakavi for MF with anemia include Luspatercept, Thalidomide, Lenalidomide, Danozole, and Erythropoiesis-Stimulating Agents (e.g., epoetin alfa, darbepoetin). Which choice would be best depends on your individual profile.

Suggest that consultation with a MPN Specialist who can review all of your treatment options would be the best way to make a decision. Emphasis is consideration of all options available.

Wishing you all the best.