Dear all
After 18 months on Besremi my oncologist and I made the decision to move on and so am starting on Rux. In brief, I titrated up from 100 ug (Sep 2022) to 500 ug Bes and was at that dose for 9 months. I was CHR for the last 5 months of this period. My platelet count however crashed in Oct 2023. I took a break from Bes for one treatment period and then restarted at 100 ug. The platelets recovered quickly as expected but my Hct started to increase. After 2 months, I needed a phlebotomy and dose was increased to 150 ug. After another month the HCT continued to increase and I upped the dose to 200 ug - this has been my dose for the last month. My HCT continues to increase and I will have a phlebotomy again tomorrow. In addition to the lack of efficacy, the side effects of Bes have been significant. Principal has been the emotional toll - anxiety, irritability and impatience. These track especially when the dose was either changed or temporarily halted. I also had uncomfortable facial flushing daily and frequent headaches - the severity of each was reduced after the dose was dropped from 500 ug to 100--200 ug but still occur. Lastly has been the skin itch. Zyrtec (thanks Hunter!) definitely helped reduce this. Taking all into account, my oncologist felt that it would be best to switch to Rux and see if that is effective and tolerable. Day 1 is today. While it is twice daily oral dose, it simplifies travel plans as it does not require refrigeration as Bes. Will keep you informed of my progress