Resveratrol with and vs Rux, bombshell claim

[EPguy]

Member Beup posted in today's feed about food vs Jak2. In checking it out I came across this one. It's regarding the supplement Resveratrol and is from from 2015 and has been posted before by Member "Hidden".

<<Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway.>>

semanticscholar.org/paper/R...

Their conclusion says << Moreover, resveratrol synergized with the selective JAK2 inhibitor ruxolitinib, eliminating tumor cells with the JAK2 mutation.>>

Who here wants their tumor cells "eliminated"?

It's behind a paywall and not amateur friendly. The only Fig I can make anything of is here. The black is inactive solvent DMSO. RVT is Resveratrol. Resver and Rux are of similar effect reducing proliferation. I can't find any figures supporting their radical claim for the combo. But it leads to the question combining it with INF.

There is a study of Resv with INF for Hep B, no publication yet that I can find. Should at least show safety results.

clinicaltrials.gov/ct2/hist...

Resveratrol is easily available. But in: ncbi.nlm.nih.gov/pmc/articl...

<<Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects. In this sense, this review summarized current data on resveratrol pharmacological effects.>>

It looks like it can be toxic in very high doses.

[Loooonglife]

Interesting! While quite exciting these data are in vitro data obtained in cultured cells and probably not quite ready for prime time. The next step would be to determine if resveratrol can show similar effects in a mouse model that carries the JAK2V617F mutation. Resveratrol has been on my radar for a long time. One caveat is thatresveratrol has low bioavailability and clinical trials have had mixed results with this compound. I have read that David Sinclair (a prominent Harvard aging researcher) seems to think that the bioavailability can be enhanced when resveratrol is administered in a suspension with olive oil. I also found one report that describes enhanced bioavailability when coadministered with piperine which is widely available.

I am wondering if a chemically related compound pterostilbene which has better bioavailability and is considered to be more potent than resveratrol may be effective as well. Both compounds have been described as activators of SIRT1, which may lead to downstream modulation of the JAK/STAT pathways.

Thanks ETguy for circulating this report!

[EPguy in reply to Loooonglife]

Bioavail seems to be a limitation of many supplements. I'm also not aware of any that really for real is proven to work on complex human conditions. The new NAC Ph1-2 trial might be one, but as usual it's for the future to know.

The "Resv with INF for Hep B" study above may have relevant info on any Resv effect, but I can't find any results for it.

[Elizka]

David Sinclair, out of Harvard, is the go-to expert on Resveratrol (sinclair.hms.harvard.edu/pe...

I take it with NMN every day, but not at high doses.

His latest podcast on RES and other longevity supplements: lifespanpodcast.com/nmn-nr-...

Also, I posted awhile back about this study on Metformin and Rux for PV:

Has anyone researched using Metformin and Ruxolitinib for Polycythemia Vera? Or spoken to a doctor about it? ncbi.nlm.nih.gov/pmc/articl...

[Beup in reply to Elizka]

Thanks for posting… I am interested in checking out his podcast.

[Paul123456]

One top MPN Hem told me that for every ten successful mouse trials, only one is successful on humans!

[EPguy in reply to Paul123456]

This study was not even that, I believe it was in vitro (lab dishes) only. That of course is a problem with supplement studies, there is not enough money there for the expensive human studies required.

[Beup]

Thanks for posting and explaining this! It’s great to find out something in your pantry might help. Loooonglife mentioned greater bioavailability with olive oil. I have my salad with my favorite Filippo Berio balsamic vinegar of Modena and olive oil. I’m wondering for myself if it is best to get in food, vs finding a “safe” supplement dose.

[EPguy in reply to Beup]

Agree on the "safe" part. There can be risk to liver and kidneys with some of them. Which ones and how risky is not easy to know. Also the purity is not well regulated.

[Beup in reply to EPguy]

I watched the Sinclair podcast Elizka posted above. While the discussion is on supplements, when asked about the French paradox, he said that having a glass of red wine(source of resveratrol) a day for 30 years builds up in the body, has a cumulative effect. Other than grapes, it is in a number of foods like berries, cocoa, peanuts. Web MD says to check with your doctor if you have a bleeding disorder before taking this supplement, and that it can interact with blood thinners.

[EPguy in reply to Beup]

I just had my quarterly Hem visit. Among many things, I asked about two supplements, NAC and Resveratrol. He's fine with NAC, which is my main interest. But he was quite strongly against Resv. I was skeptical of it myself, but this is another note to be careful with it. As always there may be patients who are suited to to it with Drs approval.

I did a low dose, short test with NAC myself last month, (I posed on it) but awaited coordinating it with him to proceed more. I will do so now.

The general idea of combos with proven MPN drugs remains interesting.

[Beup in reply to EPguy]

Good to know thanks

[Beup]

Good points thanks!

[Aldebaran25]

My bet is that a number of us will now start eating a lot more berries 😆

[cmc_ufl]

I have access to scientific articles and should be able to get a pdf of the full paper. I’ll let you know what I find.

[pvdm]

Anyone had experience with Resveratrol? What effects did it have on blood cell count and symptoms? Resveratrol is known to be better absorbed when combined with Bioperine. However, like asperine, these ingredients also have an inhibitory effect on platelets. . What side effects should I expect? Greetings Paul