I started Peg at 45 mcg weekly late March and built up slowly to around 80-90 mcg.
At last venesection mid March, my HB 135, RBC 6.32, Platelets 641 and WBC 10.95. My JAK2 Allele Burden was 75% and rising - was 55% when I was first dx Sept 2016.
Not had a venesection since.
Latest bloods HB 139, RBC 5.81, Platelets 280 and WBC 4.03. Even more impressive is that my rising JAK2 has declined to 66%.
I’ve had no Peg side effects.
Very pleased with Peg. I also have the TET2 mutation (around 15% of us PV’ers are also TET2) which is meant to inhibit the effectiveness of Peg/INF, albeit based on limited clinical data. (See recent post of mine). The TET2 mutation, as far as I understand it, increases inflammation thereby blocking Peg pathways. I follow an anti inflammatory diet so wondering if this compensates and hence my good response to Peg.