Very detailed up to date summary of INFs albeit mostly beyond my pay grade. I thought encouraging for those of us on INF/Peg but there still appear to be the two Camps of Hems - pro HU first line and pro INF first line.
For those of us who are TET2 and JAK2 +, this article is a must read. Appears the TET2 mutation implies a poorer prognosis and greater resistance to INF. something I will be discussing with my Hem next visit.
However I thought the most interesting part of the article was the impact of inflammation on the effectiveness of INF/Peg. The article cites smoking as an inhibitor of INFs.
This begs the question, does inflammatory food also inhibit the effectiveness of INFs. I know there are several ongoing MPN targeted anti inflammatory diet trials.
Maz - if you are reading this, would it please be possible to ask the Prof whether there is a chance that an anti inflammatory diet could enhance the effectiveness of INFs?
I appreciate that there is probably no hard clinical evidence but if there is a chance, I can’t see the downside of being pre-emptive. After all, an anti-inflammatory diet pretty much equates to a healthy diet anyway, reduce refined sugars, carbs, processed food etc.