link.springer.com/article/1...
Very detailed up to date summary of INFs albeit mostly beyond my pay grade. I thought encouraging for those of us on INF/Peg but there still appear to be the two Camps of Hems - pro HU first line and pro INF first line.
For those of us who are TET2 and JAK2 +, this article is a must read. Appears the TET2 mutation implies a poorer prognosis and greater resistance to INF. something I will be discussing with my Hem next visit.
However I thought the most interesting part of the article was the impact of inflammation on the effectiveness of INF/Peg. The article cites smoking as an inhibitor of INFs.
This begs the question, does inflammatory food also inhibit the effectiveness of INFs. I know there are several ongoing MPN targeted anti inflammatory diet trials.
Maz - if you are reading this, would it please be possible to ask the Prof whether there is a chance that an anti inflammatory diet could enhance the effectiveness of INFs?
I appreciate that there is probably no hard clinical evidence but if there is a chance, I can’t see the downside of being pre-emptive. After all, an anti-inflammatory diet pretty much equates to a healthy diet anyway, reduce refined sugars, carbs, processed food etc.
Thanks Paul
Hi Paul,
Thanks for the link to the article. It is very interesting and positive in its outlook.
John