Thyroid

[ChillyAsh34]

Has anyone on hydroxycarbamide for ET+JAK 2 and on thyroxine for under active thyroid and aspirin had any interaction between the meds I am sure I am getting symptoms of under activity from thyroid so have got a thyroid function test tomorrow

[Superwoman]

Hi ChillyAsh, I have ET JAK 2 positive also have an under active Thyroid and take Thyroxin. Diagnosed with ET since 2013 but had under active thyroid a lot longer. I alway make sure I take my Thyroxin first thing in morning before any tea or coffee and eating, then I take my Hydroxycarbamide after breakfast with plenty of water. I also have my thyroid checked every three to six months, and have just had the amount I take changed as it started going overactive, triggering palpitations, and stomach problems. Been put down to 50 mg Daily and 75mg at weekend, which seems to of helped, due to have blood test next month, so will see if this has worked.But apart from that all works well with Hydroxycarbamide, but spacing them out when taking does help.

Jean

[ChillyAsh34 in reply to Superwoman]

Thank you superwoman my last check on thyroid was March this year all was fine ,but platelets night a few more blood test a then hematologist appointment in June revealed E

T and JAK 2mutation all was well till 3weeks ago when my hydroxycarbamide was upped to one extra on a sat and sun ,when the pain came in the back of my right knee and I have a concern about my body bloating like when my thyroid was first diagnosed 30 yrs ago my thyroxine not changed in years

[Superwoman in reply to ChillyAsh34]

Hi Chillyash, I take 500g daily, then 1.000mg Fri-sun. Is there a swelling at the back of your knee as it could be a bakers cyst which are very painful.I have been taking Thyroxin for over twenty five years as well, but my Doctors have always kept an eye on it with blood tests, this was one reason that one time they decided to do a full blood count as I was constantly unwell with one thing or another that they were not putting down just to Thyroid problems, this was when I was referred to a Haematologist to have the JAK 2 Mutant test done which came back positive, the rest is history.

Joint pain is very common with ET plus fatigue, but please get the pain checked out behind your knee as about eight years ago I had a similar pain could hardly walk turned out my knee was bone on bone and ended up having a total knee replacement. So

Ask your Doctor if you can get it X-rayed.

Not sure if thats any help, but I do not think that the Thyroxin is interacting with the Hydroxycarbamide well it’s highly unlikely. There are a few people on this forum who take these two drugs daily.

Take care

Jean

[ChillyAsh34 in reply to Superwoman]

Thanks for imput ,I do have a swelling at back of knee get it checked tomorrow funny I don't suffer fatigue thank goodness ,apart from back of knee I feel great

[Superwoman]

Let us know how you get on.

[ChillyAsh34 in reply to Superwoman]

Will do ,weird tonight the pain is almost gone

[Superwoman]

The trouble with bakers cysts is that the pain can come and go. So definitely get it checked.Jean

[Anag]

I have Hashimoto since over 40 years. I tried the HU and have neurological problems starting the second day. Stopped immediately. Am on Anagrelide instead. I don’t know if this reaction had anything to do with the thyroid med. but I take bioidentical bovine hormoneninstead of the chemical replacement T4 Thyroxine.

[Oscarsboy]

Morning ChillyAsh. I have been on thyroxin over 30 years now and take 125 mg per day. I have been on Hydroxy since August and so far do not seem to have encountered any problems with both meds. I take Thyroxin first thing before breakfast, then Hydroxy after lunch and aspirin before I go to bed. I too have thyroid checked every three months and due for another one in January. It is good you are having it checked now so that it can be readjusted if necessary. Hope all goes well.

[ChillyAsh34 in reply to Oscarsboy]

Thanks oscarsboy I was taking thyroxine and hydroxycarbamide and aspirin with in an hour of each other ,I how take my thyroxine in the morning as usual about 8am aspirin at 10 am with food then 3pm hydroxycarbamide it seems better leg is almost painless now so I will stay with this

[Oscarsboy]

Great. Its good to find a routine that suits isnt it.

[grannieblue]

Hi ChillyAsh34, I have been taking Hydroxy for just over a year and have not had any changes in thyroid results, have been taking 200thyroxine daily for more than 25 years. Pain and swelling behind the knee can be due to a build up of synovial fluid as a result of arthritis. I have had both hips replaced and need a new knee..ugh!! Generally I feel tired and with generalized pain which many people report on this forum...? just the MPN. Worth checking your B12 and vit D levels. I also take folic acid.Hope your knee is sorted soon,it's a horrible pain.