Happy New Year to all the members of this invaluable group! Does anyone have experience switching from Pegasys to Ruxolitinib? I am considering a switch in meds since my allele burden seems to be suddenly climbing after 3 successful years on Pegasys. Pegasys has been very good to me apart from developing hypothyroidism. It has kept my blood under control fairly well, and I have managed minimal side effects (after the initial startup). I have my semi-annual appt with MPN specialist in a few weeks and collecting my thoughts on next steps.
I am JAK2+ pre-fibrotic MF, 45 years old. My thyroid went out after about a year on Pegasys - not stoked about that but I will deal. I would love to be able to get thyroid up and running again if I discontinue Pegasys.
Also wondering if Besremi would be better suited for my sluggish thyroid. Does anyone know if Besremi is a little gentler on the thyroid?
Any input on your experiences would be greatly appreciated.