Vaccine antibodies

[Paul123456]

Be interesting if we all listed our results on one thread

I’m now 203 u/ml at 4 months (2nd jab at 2 months). My hem, who is involved in the Oxford trial said over 50 u/ml is a very good level of protection. Said a trial of over 50’s NHS workers was 600-800 u/ml after one jab.

This doesn’t measure T cells etc so is broad brush and we all may be getting more protection than the headline figure. And I assume his 50 u/ml is for the most vulnerable and oldest

This is a link to another trial

nature.com/articles/s41375-...

[mhos61]

Good idea.

My results: 2239 U/ml four weeks after second AZ vaccine.

As requested, lymphocyte count: January (2021) 1.8. April (2021) 2.3.

Age 66

[Whitehair51]

Please also note your age, elderly may have a reduced response.

[Tertia3]

Great idea, Paul.My result is >250 U/ml . Sample taken 4 weeks after my 2nd Oxford Astra Zeneca vaccination. My WBC is midway through the reference range. I'm 69.

[KiHi]

Mine was 911 U/ml 3 weeks after 2nd Pfizer shot. I had mine checked by the study conducted by The leukemia and lymphoma society for any blood cancer patients. I’m 46, JK2 positive. Not on any medication yet.

[jmctrek in reply to KiHi]

Is this study with the LLS still ongoing?

[KiHi in reply to jmctrek]

Yes, I think so. The below is the link! I registered online, printed a lab slip, went to a near by lab corp. to get my blood drawn. The LLS pays for it. No cost to you at all. They check both antibody by past covid infection, and spike antibody by vaccine. Got a result next day.

ciitizen.com/LLSCOVIDStudy/...

[Minu68 in reply to KiHi]

Thank you!! Just registered but appears to be US only.....I'm in the UK

[KiHi in reply to Minu68]

Sorry, I should have mentioned it’s for US. I live in California.

[Minu68 in reply to KiHi]

No worries, I lived in California many many years ago, San Marino, did au pairing job x

[KiHi in reply to Minu68]

San Marino in Los Angeles county? I’m in Los Angeles too:).

[Minu68 in reply to KiHi]

yes I did enjoy my year there, was 18 years old, and worked for a lovely family, have happy memories of that time! xx

[KiHi in reply to Minu68]

Good to hear you have a happy memories here:). 18! The life was so much simpler then! I’m new to this site and just starting my MPN journey. Thank you for your friendly replies:). I will make a post and properly introduce myself when I’m ready. I’m still struggling to adjust to new normal. Thank you very much for your warm welcome, Minu😘

[Minu68 in reply to KiHi]

Ah kihi, I’m still adjusting too, diagnosed February 2020. Taking your time is perfect, there’s so much to take in never mind processing the diagnosis. I’ve found this forum great for information and support, welcome to this group of people who in an ideal world would never be here! I’ve never done a formal introductory post, don’t feel you have to if it feels like too much Take care xx

[jmctrek in reply to KiHi]

Thank you for the link KiHi. I registered online and downloaded the lab slip for my next blood draw. I’m hesitant to complete my profile with Ciitizen to digitize my medical records (it requires a driver’s license upload) and plan get the results from LabCorp directly.

I can understand your sentiment about adjusting to a new normal. It was dreadful to be told I was jak2+ during a pandemic, but the stay at home orders actually created space for me to reflect on my future, and the slow reopening of California has been helpful in allowing me to reconnect with family and friends on my own time and pace.

I’m glad you have joined this group and hope you will find the support and community you need on this forum.

[PT99]

Can we draw from this that those with MPNs are getting a good level of protection then?

In the broadest possible terms, those diagnosed with blood cancer per se, are seeing no antibodies at all following vaccination.

How can I get an antibody test?

Thanks

Pete

[mhos61 in reply to PT99]

The antibody test that most are referring to is from a company called, ‘Testing for All’. It is the ‘Covid-19 Immunity Tracker’ test, which measures antibody levels to the spike protein after vaccination. It costs £49.

Maybe take a look on their site, do your own research and see is it for you.

[Paul123456]

Clearly timing is critical, especially with the AZ vaccine which builds up slowly. Mine went from 2.1 at day 20 to 203 at four months.

Might be interesting if responders noted their Lymphocyte count, which is a proxy for B cells and T cells. Do people with normal Lymphocytes always get a good response and people with low Lymphocytes normally get a more muted response ie lower antibodies.

My Lymphocytes are 0.45. My wife registered 270 u/mg after only one jab (eight weeks).

[PT99]

Paul,

Sorry, I don’t understand the numbers but are we seeing a good response to the vaccine in MPNs then?

Thanks

Pete

[KiHi in reply to PT99]

My understanding is Yes, there is a good response at least with Pfizer vaccine based on the study linked below. As far as number goes, anything above 0.7 is considered positive for spike antibody created by vaccination.

google.com/amp/s/www.news-m...

[PT99 in reply to KiHi]

Thanks. I had the AZ so would be interesting to know if there are any case studies for that one.

[Paul123456 in reply to PT99]

Pete

My working theory, and I’ve got a consult on Tuesday so will confirm, is that if you have good Lymphocytes (ie T cells and B cells) you should get antibodies. I think the blood cancer patients you refer to have impaired B cells, perhaps as a result of immunosuppressant drugs.

I have very low Lymphocytes (0.45) but have still had a reasonable response (as in well protected) albeit not remotely as good as my wife’s.