Pfizer vaccine effective in patients with MPNs - MPN Voice

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Pfizer vaccine effective in patients with MPNs

Ovingite profile image
48 Replies

This may not be new news, but it is good news that I wanted to share! The link will take you to a Covid-19 press release by Pfizer, based on research by our own Guys & St. Thomas' MPN team.

In summary, results show 86% of those MPN patients tested who had just one dose of the Pfizer jab exhibited antibodies against the spike protein that causes C-19. Furthermore, 76% of those tested also had a T cell response. The research was conducted from a small sample of 21 patients - inevitable with rare diseases, but the outcome is a strong indication that the vaccine works. My personal (i.e. not scientifically proven) view is that two jabs will provide an even higher level of protection. What a relief!!!

All the best

John

news-medical.net/news/20210...

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Ovingite profile image
Ovingite
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48 Replies
EmeraldA profile image
EmeraldA

Great news!!!!!! I hadn't seen this. So thanks for posting. B :)

sweetpea19 profile image
sweetpea19

Thankyou for posting . Thanks to all those involved in the ongoing research on our behalf I’m feeling more reassured that we do have some protection

piggie50 profile image
piggie50

Good news! Thanks for posting.

Cja1956 profile image
Cja1956

Hi, John. I live in the US and the Leukemia and Lymphoma society also did a study on people with all types of blood cancers and those with MPNs were 97% protected from COVID if they had 2 injections of Pfizer. I will try to see if I can post the article but I haven’t figured out how to do that yet. Of course, now the news is saying that the effectiveness of the vaccine starts wearing off after 6 months for everyone, so that’s really worrisome. In my state, the Delta variant is spreading like wildfire. So I’m back to wearing my mask when I go out. About 91% of those hospitalized with COVID are not vaccinated, so we can be assured that if we do get it, it will be a mild case, hopefully.

Ovingite profile image
Ovingite in reply to Cja1956

Thanks for the info. 97% for 2 jabs is even better than I hoped for - but I'm still wearing my mask in shops and places with too many people. We have our share of vaccine deniers too (though I know some have a valid health reason for not masking up)Stay safe

John

MaggieSylvie profile image
MaggieSylvie in reply to Ovingite

My local denyers say that it's a matter of choice - theirs not to be jabbed and mine to stay at home.

Emmyroos profile image
Emmyroos in reply to Cja1956

Great to know. I gave blood for this study but didn't know they had published the results. That's a relief to know it works.

Meatloaf9 profile image
Meatloaf9 in reply to Cja1956

Hi Cja, thanks for the report. Do you know if the L & L Society report had any information on MPN patients taking cytoreductive therapy such as HU or Rux or Interferon?Thanks again.

lynda1ann profile image
lynda1ann

That’s fantastic news, but what about the AstraZeneca Where do we stand with that one…..

Ovingite profile image
Ovingite in reply to lynda1ann

Not sure. I remember Prof Harrison saying at the beginning of this trial that they went with Pfizer as it was the first to be released and it was what most MPN patients had been given at the time.Blood cancer UK are running a webinar on Monday at 6pm. You might be able to get more information from them? I think you are asked to submit questions to the panel in advance if possible.

All the best

John

Minu68 profile image
Minu68 in reply to lynda1ann

I had AstraZeneca too, and been thinking the same Linda1ann . only got vaccinated early this year as my haematologist and gp decided ET didn’t classify as extremely vulnerable, until blood cancer and prof Harrison issued the letter to gp, and managed to persuade haematologist…

Thanks for sharing the webinar is on, didn’t know!

MaggieSylvie profile image
MaggieSylvie in reply to lynda1ann

Have you seen the MSN news? It says Pfizer on top of AZ is excellent.

lynda1ann profile image
lynda1ann

Hello, Thank you for your reply. I will have a look at blood cancer uk. X

ksos profile image
ksos

Thanks for sharing this -- great news!

Swede profile image
Swede

Hi, I have been checked for antibodies (twice) and sadly I don't have any. I am all for a booster in a couple of months.

Ovingite profile image
Ovingite in reply to Swede

Very sorry to hear that. I guess not all vaccines will work in all people, whatever the disease. I hope the autumn booster gives you protection.John

Dan73 profile image
Dan73 in reply to Swede

Did you have the test for the spike protein antibodies?

Swede profile image
Swede in reply to Dan73

I have no idea. I was sent to the hospital, they took a blood sample and then I got the result , about 48 hours later.

Dan73 profile image
Dan73 in reply to Swede

My latest test had this in the lab report.

SARS-CoV-2 S Antibody Ranges

Range (U/mL) Interpretation

<0.80 Negative/Not Detected

> or=0.80 Positive/Detected

I believe the “S” refers to the spike proteins. My result was positive.

Maisie10 profile image
Maisie10

Thank you for sharing. This is good news. Take care x

Paul_1971 profile image
Paul_1971

It is good to read some positive information relating to the vaccine rather than some of the thinly veiled anti vax posts we have had of late.

There is no doubt the vaccines have been a game changer, I am not sure where we would be currently in the UK without them, perpetual lockdown probably.

GK40 profile image
GK40

What about astra zeneca as that's what I had...

Ovingite profile image
Ovingite in reply to GK40

See my reply to lynda1ann

Ettiel profile image
Ettiel

Thanks for posting this! Really reassuring.Ettiel

lizzziep profile image
lizzziep

Thanks for posting, I’ve had both doses of the Pfizer, hopefully will get the booster in the autumn.

Aldebaran25 profile image
Aldebaran25

That is great news and I believe there will be more to come from the Guy's team. They were still sampling later on after two doses . So, so glad, what a relief also for those of us on drug therapy (especially those on ruxolitnib)! thanks for this

ladyanello profile image
ladyanello

Looks like it applies mostly to MF patients.

Mal42 profile image
Mal42

Thank you, that is really helpful. I spoke to Prof Harrison the other day, no mentor this. Will ask local consultant about getting top up as I had Astra Zeneca.

Paul_1971 profile image
Paul_1971 in reply to Mal42

It looks like there are plans to give those of us who had AZ early on to get a Pfizer or Moderna booster sometime soon.

Runner999 profile image
Runner999

Hmmm. They did not send me this as promised! But from Biobank study and follow up I know that I have antibodies and that they are from the Pfizer vaccine and not from infection! I am surprised that their group was so small though - there was a general invitation put out to be part of the study.

MaggieSylvie profile image
MaggieSylvie

That is good news. I see we are to be given our boosters starting next month. And Pfizer seems to be the best of all the vaccines, especially when mixed with others.

Bluetop profile image
Bluetop

Great news. Thanks for posting. Fingers crossed for Astra Zenica

Paul_1971 profile image
Paul_1971

Of course we are all entitled to our own opinion, but it concerns me you are claiming that there is an astounding number of deaths relating to the vaccine, what evidence do you have to support this claim?

paradiastole profile image
paradiastole

What's extremely disconcerting is that you keep posting vaccine denial in a medical forum.

paradiastole profile image
paradiastole in reply to paradiastole

Here's a rebuttal of Byram Bridle's misinformation:

reuters.com/article/factche...

Here's a news story which includes more information about Francis Christian, who thinks the pandemic is a hoax:

thestarphoenix.com/opinion/...

Both of these people are, whatever their denials, anti-vaccination. It's a common tactic for anti-vaccination campaigners to say they are "just asking questions", that they are not anti-vaccine just against some vaccines, have concerns about some aspects of the vaccines, and so on. In reality, these are people who tell lies in order to discourage people from being vaccinated. The result, if they are successful, is that many people will suffer and die from preventible diseases. Why would anyone want to promote that?

Paul_1971 profile image
Paul_1971 in reply to paradiastole

I saw that its estimated in the uk alone 60000 lives have been saved by the vaccine program.

This is significant. There will be significantly less who have died from the vaccine, of course its very sad if anyone has but it will be a handful of people compared with those who have had their lives saved.

paradiastole profile image
paradiastole in reply to paradiastole

(For the avoidance of confusion, my comment about posting vaccine denial was in response to a reply which has since been deleted).

mhos61 profile image
mhos61 in reply to paradiastole

Thanks for that. This is what I assumed. What is wrong with these people...?

paradiastole profile image
paradiastole

Is this more of the nonsense about Ivermectin being a supposed cure for Covid?

in reply to paradiastole

paradiastole - absolutely not and cure - nobody has ever made that claim

paradiastole profile image
paradiastole

Francis Christian is not a virologist, he's a professor of general surgery. Or was, before he was sacked for lying about vaccines. Byram Bridle's nonsense is further debunked here: healthfeedback.org/claimrev...

Why are you so keen to deter people from being vaccinated, by spreading misinformation?

in reply to paradiastole

paradiastole - did you actually even see the podcasts/interviews etc given by these men?

paradiastole profile image
paradiastole in reply to

I don't follow cranks.

mhos61 profile image
mhos61

Can you supply reliable evidence from a credible source, such as citation from scientific experts to support the above statements?

Good supporting evidence lends credibility, without this your argument will always appear weak!

Dovme profile image
Dovme

investors.biontech.de/news-...

A press release from Biontech who created the Pfizer distributed vaccine

Believe some countries are offering third shots to high risk groups from September

Magentas profile image
Magentas

Thank you, John! I have been wondering….hard to know this type of thing living in Aus. Glad I waited for Pfizer! Have you/are you having the 3rd dose and if so how long between doses?

Ovingite profile image
Ovingite in reply to Magentas

Hi Magentas,I had my 3rd Pfizer jab 6 months after the second one, which went well apart from a day of mild flu like symptoms.

Best regards

John

Magentas profile image
Magentas in reply to Ovingite

Thanks, John. I don’t know if it’s Pfizer related but profound fatigue still going on a week later which began 2 days after my 2nd dose. Anyway, good for you, all the best.

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