📚14-08-2024 Surprising mechanism of lupus kidney damage identified

[Naladog]

I am wondering if lupus/UCTD patients are tested in their follow-up appointments about all these recent discoveries🤔 🧾

Key cells behind severe kidney damage in lupus identified

• A research team led by Charité – Universitätsmedizin Berlin has identified a small population of immune cells called innate lymphoid cells (ILCs) as key regulators of severe kidney damage in patients with lupus.

• ILCs trigger an avalanche of effects that cause harmful kidney inflammation, also known as lupus nephritis.

• The research, published in "Nature," challenges the conventional wisdom that autoantibodies are primarily responsible for lupus nephritis.

• The team found that a subgroup of ILCs with a receptor called NKp46 must be present and activated to cause lupus nephritis.

• Blocking NKp46 or GM-CSF, a protein produced by ILCs, reduced kidney tissue damage in mice, suggesting new antibody therapies for patients with severe forms of lupus.

mdc-berlin.de/news/press/su...

[KayHimm]

Naladog,

My neurologist does a cytokine panel, which is the same thing, I think. My rheumatologist says they are not yet used in rheumatology because they don’t yet know how to use the values. I guess more research is needed.

Hope you are doing well.

XxK

[Naladog in reply to KayHimm]

Thanks for your message 🤗🦋💜