Genetic clue to severe Covid: “It is part of the system that makes your immune cells more angry, and more inflammatory”...sound like lupus ?

[eekt]

Covid research will help with SLE and autoimmunity, without a shadow of a doubt!

'Two other recent studies published in the journal Science have also implicated interferon in Covid cases, through both genetic mutations and an autoimmune disorder that affects its production.'

bbc.co.uk/news/health-54832563

xxx

[DJK99]

Hey eek - I was just about to post this too! So interesting... I have gone down a rabbit hole of similar and linked med research papers instead..... Like this one :

New biomarkers in SLE: from bench to bedside

ncbi.nlm.nih.gov/pmc/articl...

There has been a lot out there about low Complement 3 and prognosis re Covid if you get hospitalised... I didn't post what I found the other day as it was a little unnerving... but if anyone is interested, it is here:

ncbi.nlm.nih.gov/pmc/articl...

I also just found this from April this year - very interesting if you're into this sort of thing!

Immunogenetics in systemic lupus erythematosus: Transitioning from genetic associations to cellular effects

diva-portal.org/smash/get/d...

The dawn of a new era of therapies in systemic lupus erythematosus

degruyter.com/view/journals...

And for all those who are negative for ANA........ as I am.... and had found some of this particular information in this article below - namely "Positive ANA is required for SLE classification and ANA remains an appropriate screening test" - and brought it up in conversation with my Rheumatologist 4mths ago, reminding him of this fact, and, very upsettingly with all sorts of things considered, the rest is history.........

Classifying and diagnosing systemic lupus erythematosus in the 21st century

academic.oup.com/rheumatolo...

Hope this isn't too much for everyone... I was an analyst pre Social Work, so I do love a bit of research... and (whatever it is at the current time) "the truth" of a thing.

Enjoy xx

[honeybug in reply to DJK99]

Wow!!!! Thank you DJK99

for this data much appreciated and very interesting.

EJ 😊🙏🌿🌸🦋

[DJK99 in reply to honeybug]

Thanks EJ! You're extremely welcome. To be honest there is so much on the web for us to read - I just put in search terms such as "SLE Covid complement" etc etc and up it comes... tons of it. So easy to find... but you can lose hours doing it.. well, I do anyway, as it's good to know a little when discussing with your clinicians I feel.. Not so sure they all feel the same way about that perhaps.. but I think it's essential if you feel in the dark about your own health, and you're not getting all the answers you need from the short time we get with our clinicians. Happy Friday! x

[honeybug in reply to DJK99]

I agree with you totally DJK that the more ammo in our cache the better communication with our docs.

I’m amazed at the amount of data we have access to if you know how to retrieve it.

I pray you’ll get good news when you see your docs again.

Have a blessed and Merry Christmas my friend.

EJ 😊🤗♥️🥰🙏🌿🌸🦋✨🎄🎅🤶

[DJK99 in reply to honeybug]

You too honeybug. Loving the emoji-fest xx

[stiff19 in reply to DJK99]

Thankyou interesting reading 👍🙏x

[eekt in reply to DJK99]

Great research! Well done! xxx

[MEGS53]

Thanks for the info eekt and DJK99. It's all very important stuff and I admit to having read only a bit of it so far (major brain fatigue these days), but my initial thoughts are that the research is in its infancy. At least they seem to be making headway in linking autoimmunity to post-covid symptoms, but there's a very long way to go. With many twists and turns, no doubt.

On a positive note, my new rheumy told me that heaps of money is in the pipeline for this kind of research - which can only be good news for auto-immuners and even more so for us 'grey area AIs' (ie those without the all-important antibodies).

Take care and have a good but safe one

🎅🎅🎅