Anti DS-DNA Binding Level 2

Hi everyone,

I'm really confused!

I'm being screened for SLE by my GP. My bloods have come back weakly positive ANA, ENA positive( apparently this was done off the back of the ANA, and it doesn't seem to specify the antibodies normally included in that panel) and this baffling statement about binding levels.

Does anyone have a clue what this means?

I'm of a mind to believe that its negative at the moment, but I have been referred by my doctor to a Rheumatologist for the avoidance of doubt.

Many thanks in advance for your help!

4 Replies

  • Hi BettieJ,

    I'm afraid I have not heard any reference to a binding level of anti-dsDNA antibodies before and I cannot find any relevant information in the books we have access to. Does your GP know?

    Do you have an appointment through to see a rheumatologist yet?

  • Hi Paul,

    Thanks for trying to answer my query.

    I have an appointment with a Rheumatologist next month, so I hope they'll be able to give me an answer then.

    My GP is lovely, but about as useful as a chocolate teapot when it comes to explanation, and getting an actual face to face appointment is harder than arranging an audience with the Pope,so I'll have to put up with the mystery until the next round of blood and urine tests(ASMA/lipids/ACR ratio)

    Thanks once again,


  • Sorry I can't help more. Please let us know what your rheumatologist says when you see them.

  • If the ana is positive it is suggestive of SLE. The dr will then go on to do a DS DNA to exclude/confirm the diagnosis of SLE.

    There is a further test which will probably be ordered by the rheumatologist.

    BH may know the name of this test if not The Doctors Laboratory will give u free info.

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