Hello, I am taking methotrexate and prednisone, my doses are about what most of you list that you are on: Methotrexate 15.5 mg weekly, 6 tablets of 2.5 mg each Monday, prednisone 5 mg each day and folic-acid 1000 mcg daily. I've been on these meds since June 29, 2015, and of lately have noticed that I am experiencing strange symptoms such as: Memory problems- forgetfulness, problems articulating orally what I am thinking or needing to say, a kind of brain-fogginess. Also, I am way more tired than I should be or so I believe. Let's just say my body wants to be up, now that I am not hurting as much physically, but my mind is tired. Where before the meds I was physically hurting so much that it eventually affected my mental state of being. Lastly, sometimes I feel as if I've either been drugged or been drinking too much, zombie out. Has anyone else experienced these symptoms?