I have been in methotrexate for 5 weeks now. I am having injections 7.5 mg as the tablets made me feel so sick. It is making me so tired! Feel like I have been hit by a bus the day I have it then very tired for a few days. Does this get easier? Sickness has eased a lot just so tired and achy. Taking folic acid once a week. I also find that by the day before i am due the next injection that my joints are worse like the effects are wearing off. Does anyone else experience this?